ABSTRACT
We report two cases of autoimmune pancreatitis (AIP) in which fluorine-18 fluorodeoxyglucose (FDG) showed moderate accumulation in the pancreas, as well as in bilateral submandibular glands and in multifocal lymph nodes. FDG positron emission tomography (PET)/computed tomography (CT) is a useful diagnostic tool to assess the extrapancreatic lesions of AIP, which is a recently proposed new clinicopathological entity named immunoglobulin G4 (IgG4)-related systemic disease. Recognition of the FDG-PET/CT findings of IgG4-related sclerosing disease is crucial to avoid unnecessary surgery or other intervention because of similarities to malignant lymphoma or malignant tumor with multiple lymph node metastases.
Subject(s)
Fluorodeoxyglucose F18/pharmacokinetics , Lymphoma/diagnostic imaging , Pancreatitis/diagnostic imaging , Pancreatitis/pathology , Salivary Gland Neoplasms/diagnostic imaging , Aged , Autoimmune Diseases , Cholangiopancreatography, Magnetic Resonance , Diagnosis, Differential , Fibrosis/diagnostic imaging , Humans , Immunoglobulin G , Immunohistochemistry , Male , Neoplasm Metastasis , Positron-Emission Tomography , Radiopharmaceuticals/pharmacokinetics , Salivary Gland Neoplasms/secondary , Submandibular Gland/diagnostic imaging , Submandibular Gland/pathology , Tomography, X-Ray ComputedABSTRACT
We report on a case with an inflammatory pseudotumor of the spleen, which showed a moderate accumulation of F-18 fluorodeoxyglucose (FDG) in the tumor. F-18 FDG accumulated mainly in the peripheral portion of this tumor that showed abundant hypercellular inflammatory cells histopathologically. Splenic inflammatory pseudotumors should be recognized as F-18 FDG-avid benign tumors of the spleen.
Subject(s)
Fluorodeoxyglucose F18/pharmacokinetics , Granuloma, Plasma Cell/diagnostic imaging , Granuloma, Plasma Cell/diagnosis , Spleen/diagnostic imaging , Humans , Male , Middle Aged , Positron-Emission Tomography , Radiopharmaceuticals/pharmacokinetics , Spleen/pathologyABSTRACT
We report two cases of young women with a solid pseudo-papillary tumor of the pancreas which having cystic and hemorrhagic components with marked calcification on computed tomography and magnetic resonance imaging. F-18 fluorodeoxyglucose positron emission tomography revealed abnormally increased accumulation of F- 18 fluorodeoxyglucose in the pancreas tail tumors, especially in the non-calcified solid portion of the tumors. These patients underwent elective resection of the masses and distal pancreatectomy and were diagnosed with solid pseudo-papillary tumors by histopathological analysis. There was no evidence of distant metastasis on follow-up after surgery and they showed no histopathological findings suggesting malignancy. These cases suggest that solid pseudo-papillary tumor may show high uptake of F-18 fluorodeoxyglucose.
