Subject(s)
Bone Neoplasms/surgery , Histiocytoma, Benign Fibrous/surgery , Adolescent , Adult , Age Factors , Aged , Bone Neoplasms/diagnostic imaging , Child , Diagnosis, Differential , Female , Histiocytoma, Benign Fibrous/diagnostic imaging , Humans , Male , Middle Aged , Prognosis , Radiography , Sex FactorsABSTRACT
An osteolytic bone tumor was found in a 12-month-old male NZB mouse. Macroscopically and histologically this tumor was angiosarcoma originating in bone with distant metastasis present in the spleen. The primary tumor was successfully transplanted in the back subcutaneous tissue of syngeneic mice, and the characteristics of the transplants, were found to be similar to those of the primary tumor. The ultrastructure of tumor is described.
Subject(s)
Bone Neoplasms/veterinary , Hemangiosarcoma/veterinary , Mice, Inbred NZB , Rodent Diseases/pathology , Tibia , Animals , Bone Neoplasms/pathology , Bone Neoplasms/ultrastructure , Hemangiosarcoma/pathology , Hemangiosarcoma/ultrastructure , Male , Mice , Neoplasm Transplantation , Transplantation, HomologousABSTRACT
Five cases of malignant fibrous histiocytoma originating in the femur and tibia, sometimes with local recurrences, are reported. Histological and clinical characteristics of this lesion were similar to those in soft tissues with the same disease. The present histiocytomas were observed by electron microscopy and shown to consist of 5 types of neoplastic cells which were regarded as undifferentiated cells, histiocyte-like cells, which were predominating, fibroblast-like cells, multinucleated giant cells and xanthomatous cells. These findings led us to confirm the existence of malignant fibrous histiocytoma originating in bone as well as in soft tissues.
Subject(s)
Bone Neoplasms/ultrastructure , Histiocytoma, Benign Fibrous/ultrastructure , Adult , Cell Nucleus/ultrastructure , Female , Femur/ultrastructure , Fibroblasts/ultrastructure , Histiocytes/ultrastructure , Humans , Inclusion Bodies/ultrastructure , Male , Microscopy, Electron , Middle Aged , Soft Tissue Neoplasms/ultrastructure , Tibia/ultrastructureABSTRACT
Existence of an entity called malignant fibrous histiocytoma of bone was emphasized, based on two of our own cases experienced recently and on previous reports related to this tumor. Histologically the tumor resembles markedly the malignant fibrous histiocytoma originating in the soft part. In addition, an attempt was made to clarify its biological behavior, histological subclassification and criteria to be malignant and differential diagnoses from several other bone diseases which sometimes mimic this malignant bone tumor.
