Diarrheal deaths in children living in New Mexico: toward a strategy of preventive interventions.

We reviewed 26 childhood diarrheal deaths examined by the New Mexico Office of the Medical Investigator, from 1980 through 1989, to identify circumstances surrounding the illness that might lead to strategies for prevention. Children who died were younger than 9 months of age (88%) and were from minority groups (American Indian 54%, Hispanic 23%); 12 (46%) had seen a physician within 3 days of death. Interventions to avert these deaths include educating parents to seek earlier treatment and health care providers to recognize that acutely dehydrating diarrhea can be fatal.

Injuries and risk factors for injuries from the 29 May 1982 tornado, Marion, Illinois.

On 29 May 1982, a tornado struck Marion, Illinois. As a result, ten people were killed, 38 were hospitalized, and 196 were examined in hospital emergency rooms. In order to describe injuries and to identify risk factors that might have increased or reduced the risk of injuries, we (1) conducted a telephone survey of all persons we could identify who were in the path of the tornado and (2) reviewed the emergency room logs and records and admission files of hospitals that provided initial care. Overall, 19.3% of people who were in the path of the tornado were injured during the impact. Only 39.0% of people examined in emergency rooms were injured as a direct result of the impact. The remainder were injured while rescuing, cleaning up, or just walking in the disaster area. Behaviours that were most protective were being in a house on the lowest floor, staying underground in a basement, protecting one's body with something like a blanket, and staying away from windows. Neither lying down nor opening doors or windows seemed to decrease the risk of being injured. Our results emphasize the need for early warnings and public education about protective behaviours.

Canine serum levels of polychlorinated biphenyls (PCBs): a pilot study to evaluate the use of animal sentinels in environmental health.

To evaluate the potential for using domestic animals in the surveillance of environmental exposures, we collected serum samples for polychlorinated biphenyl (PCB) analysis from nine dogs in Monroe County, Indiana, where people had been shown to have been exposed to PCBs. Nine dogs in Atlanta, Georgia, served as comparisons. Results indicated that canine serum PCB levels in contaminated areas (median = 3.0 ppb) tend to be greater than those in uncontaminated areas (median = 1.7 ppb [p = .06, Mann-Whitney U test]). This finding suggests that pet dogs may serve as sentinels of human exposure to environmental PCB contamination.

Microsomal biphenyl hydroxylase of fall armyworm larvae and its induction by allelochemicals and host plants.

Biphenyl was hydroxylated to 4-hydroxybiphenyl by a mixed-function oxidase system from midgut microsomes of fall armyworm (Spodoptera frugiperda) larvae. Optimum conditions for assaying the enzyme were established. The microsomal biphenyl 4-hydroxylase activity increased during larval development and declined in the prepupa. Allelochemicals (monoterpenes, indoles and flavones), drugs (phenobarbital and 3-methylcholanthrene) and host plants were found to induce the hydroxylase. The enzyme was also found to be fairly active in other species such as velvetbean caterpillars, corn earworms, tobacco budworms, mole crickets, American cockroaches and honey bees.

The 1990 objectives for the nation for injury prevention: a progress review.

Unintentional injuries are the principal cause of preventable early death. Beyond terms of human suffering and death, injuries place enormous burdens on this country's economic and health care resources. Demographic, sociological, environmental, and behavioral factors that influence our society contribute to the complexity and scope of the injury problem. Progress in injury prevention will be achieved only through the combined efforts of individuals, organizations, and government at every level of our society. The Federal Government is an important contributor to this process through its role of leading, catalyzing, and providing strategic support. Within the Department of Health and Human Services, numerous agencies have major injury prevention components with a broad range of responsibilities, including the direct delivery of services, establishment of safety standards, sponsorship of education and information efforts, building of the capacity of other sectors, basic and applied research, and surveillance. The Centers for Disease Control, as the lead agency, assists State and local health departments in their injury prevention efforts and coordinates activities undertaken jointly by Federal agencies, State and local governments, and private-sector organizations. To meet the 1990 Objectives for the Nation with respect to injury prevention, both the public health and private-sector providers must recognize the injury problem of the 1980s. Without the support and involvement of the public health and provider communities and of the private sector, injuries and their costs will continue at their present alarming rates. The opportunity is great for promoting health, preventing injuries, and reducing associated costs to society. Making the best of this opportunity is our challenge during this decade.