1.
Org Biomol Chem
; 13(10): 3116-21, 2015 Mar 14.
Article
in English
| MEDLINE
| ID: mdl-25633433
ABSTRACT
Four substituted cis and trans-4,5-dihydroxyhexahydropyridazines that were expected to undergo pH induced conformational switching were synthesized and carefully investigated by NMR analyses and calculations. For two of the compounds a large difference in pKa existed between the two possible chair conformers and for one compound this resulted in conformational switching as a result of pH change. For the first time it is shown that the pKa directly reflects the conformational equilibrium of conformers.