El cuerpo como objeto de deseo en obesos mórbidos con antecedentes de abuso sexual / The body as an object of desire in morbidly obese patients with a history of sexual abuse

Introducción: La imagen corporal del obeso mórbido puede ser usada como factor de protección frente a la sexualidad. Se ha hipotetizado que los sujetos con antecedentes de abuso sexual serían más proclives a utilizar la obesidad mórbida en este sentido. Acercarnos a la verificación de esta hipótesis en una muestra de 398 pacientes con obesidad mórbida que solicitan intervención de cirugía bariátrica. Método: Entrevista semiestructurada con recogida sistemática de datos, de los abusos sufridos y de las vivencias y repercusiones de la obesidad en las relaciones sexuales de los pacientes. Resultados: la mayoría de los pacientes entrevistados con antecedentes de abusos sexuales eran mujeres (n=39; 88,6%). Los pacientes con antecedentes de abusos sexuales presentaban una comorbilidad psiquiátrica mayor y menor autoestima (2.60 OR (1,32-5,13) aunque la obesidad no representaba un problema en sus relaciones sexuales 1.52 (0,71-3,24)). Conclusión: La utilización de la imagen corporal del obeso como barrera de protección ante la sexualidad no requiere del antecedente de abuso sexual (AU)

Background: Morbid obesity may use their body image in order to avoid attracting erotic attention. Some authors have suggest that people who have been sexually abused are likely to used their body image in that way. We try to attempt to verify this hypothesis in a sample of 398 morbidly obese patients who requested bariatric surgery. Method: A semi-structured interview with systematic collection of information regarding the abuse suffered and the experiences and repercussions of obesity on the patients’ sexual relations. Results: The majority of patients interviewed with a history of abuse were women (n=39; 88.6%). Patients with a history of sexual abuse presented higher psychiatric comorbidity and lower self-esteem (2.60 (1.32-5.13), although the belief and convictions of interference of their body image in their sexuality was similar to those who had not suffered sexual abuse (1.52 (0.71-3.24)). Conclusion: The use of an obese subject’s body image as a protective barrier against sexuality does not require a history of sexual abuse (AU)

Oestrogen receptor polymorphisms are an associated risk factor for mild cognitive impairment and Alzheimer disease in women APOE {varepsilon}4 carriers: a case-control study.

OBJECTIVES: Examine the role of single nucleotide polymorphisms (SNPs) in the oestrogen receptor (ER) genes: rs9340799, rs2234693, rs2228480 (in the ESR1 gene) and rs4986938 (in the ESR2 gene) as a risk factor for amnesic mild cognitive impairment (MCIa) and Alzheimer's disease (AD) and its possible association with the apolipoprotein E (APOE) gene. DESIGN: We have investigated the independent and combined association of different alleles of the oestrogen receptor genes and APOE*ε4 allele with cognitive impairment using a case-control design. SETTING: Participants were prospectively recruited from the neurology departments of several Basque Country hospitals. PARTICIPANTS: This study comprised 816 Caucasian participants who were aged 50 years and older: 204 MCIa, 350 sporadic patients with AD and 262 healthy controls. PRIMARY AND SECONDARY OUTCOME MEASURES: Clinical criteria and neuropsychological tests were used to establish the diagnostic groups (MCIa, AD and healthy controls). A dichotomous variable was used for each allele and genotype and the association with MCIa and AD was established using Logistic Regression Models. RESULTS: Neither alleles nor genotypes of SNPs rs9340799, rs2234693, rs2228480 and rs4986938 of oestrogen receptor genes (ESR1 and ESR2) are independently associated with the risk of MCIa or AD. However, the genetic profile created with the combination of the less represented alleles of these SNPs (expressed as XPAA) was associated with an increased risk for MCIa (OR=3.30, 95% CI 1.28 to 8.54, p=0.014) and AD (OR=5.16, 95% CI 2.19 to 12.14, p<0.001) in women APOE*ε4 allele carriers. CONCLUSIONS: The less represented alleles of SNPs studied are associated with MCIa and AD in APOE*E4 carriers. In particular, the genetic profile created with the less represented alleles of ESR1 and ESR2 SNPs are associated with an increased risk for MCIa and AD in women APOEε4 allele carriers.