Subject(s)
Acanthosis Nigricans/complications , Hyperandrogenism/complications , Insulin Resistance , Acanthosis Nigricans/diagnosis , Adolescent , Facial Expression , Fatty Liver/complications , Fatty Liver/diagnosis , Female , Humans , Hyperandrogenism/diagnosis , Hypotension/complications , Intellectual Disability/complications , Intellectual Disability/diagnosis , Obesity/complications , SyndromeABSTRACT
Autologous bone marrow transplantation (ABMT) often produces durable remission in patients with intermediate-high grade non-Hodgkin's lymphoma (NHL). We present a retrospective review of 32 eligible newly diagnosed patients with NHL treated with conventional induction chemotherapy followed by ABMT consolidation therapy. These patients were treated in our department between 1984-1994 and followed up for 5-172 months with a median time of 82 months. In our patients the status of disease at transplant was 30 complete remissions and 2 partial remissions. All patients received a CBV-like high-dose preparative regimen. At 136 months the probability of disease-free survival (DFS) and overall (OS) is 66% and 70% respectively. Seven patients died from the disease. There was one case of toxicity related death. Our aim was to achieve a status of minimal disease and then consolidate it with high-dose polychemotherapy regimen. This study confirms that a significant number of patients with aggressive responding NHL can achieve prolonged RFS and OS after ABMT. Our data document the importance of long-term follow-up in interpreting the results of ABMT in NHL.
Subject(s)
Bone Marrow Transplantation , Lymphoma, Non-Hodgkin/therapy , Adolescent , Adult , Antineoplastic Combined Chemotherapy Protocols/adverse effects , Antineoplastic Combined Chemotherapy Protocols/therapeutic use , Bone Marrow Transplantation/adverse effects , Combined Modality Therapy/adverse effects , Disease-Free Survival , Female , Humans , Intestinal Mucosa/pathology , Life Support Care , Lymphoma, Non-Hodgkin/drug therapy , Lymphoma, Non-Hodgkin/pathology , Male , Middle Aged , Mouth Mucosa/pathology , Neoplasm Staging , Neutropenia/etiology , Palliative Care , Retrospective Studies , Stomatitis/etiology , Thrombocytopenia/etiology , Time Factors , Transplantation, Autologous , Treatment OutcomeABSTRACT
The authors describe a case of multiple myeloma that developed several extraskeletal localizations. They evaluated the relation between the onset of the testicular tumor and the following myeloma characteristics: tumor burden, clinical phase, response to therapy and prognostic significance. The patient presented a rapid and dramatic clinical evolution of the disease with extensive spread also to the soft tissues of the abdominal wall. Chemotherapy did not achieve any effect and the patient died due to progression of the myeloma.