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1.
Parasitol Res ; 116(10): 2683-2694, 2017 Oct.
Article in English | MEDLINE | ID: mdl-28785847

ABSTRACT

Lymphatic filariasis (LF) affects 73 countries, causes morbidity and impedes socioeconomic development. We had found no difference in safety and micro (Mf) and macro filarial action of single-dose diethylcarbamazine (DEC) and DEC + albendazole (ABZ) in an F01 study done in India (year 2000). There was a programmatic need to evaluate safety and efficacy of multiple annual treatments (F02). Subjects (155) from the F01 study, meeting inclusion-exclusion criteria, were enrolled in F02 and treated with further two annual doses of DEC or DEC + ABZ. Efficacy was evaluated for Mf positivity by peripheral smear (PS) and nucleopore (NP) filter, circulating filarial antigen (CFA) and filarial dance sign (FDS) positivity and Mf count at yearly follow-up. Safety was assessed for 5 days after drug administration. Total of 139 subjects evaluated for efficacy (69 DEC and 70 DEC + ABZ group). Mf positivity prevalence declined progressively by 95% (PS), 66% (NP), and 95% (PS) and 86% (NP); CFA positivity prevalence declined by 15% and 9%; FDS by 100% each; Mf count declined by 75.5 and 76.9% with three annual treatment of DEC and DEC + ABZ, respectively. Addition of ABZ did not show any advantage over DEC given as three annual rounds for LF. DEC and DEC + ABZ were well tolerated. There was no correlation between result of CFA and FDS, (both claimed to be indicative of adult worm). Analysis of published studies and our data indicate that macrofilaricidal effect of DEC/DEC + ABZ may be seen in children and not adults, with three or more annual dosing.


Subject(s)
Albendazole/therapeutic use , Diethylcarbamazine/therapeutic use , Elephantiasis, Filarial/drug therapy , Filaricides/therapeutic use , Wuchereria bancrofti , Adult , Albendazole/administration & dosage , Albendazole/adverse effects , Animals , Antigens, Helminth/blood , Diethylcarbamazine/administration & dosage , Diethylcarbamazine/adverse effects , Double-Blind Method , Drug Administration Schedule , Drug Therapy, Combination , Elephantiasis, Filarial/epidemiology , Female , Filaricides/administration & dosage , Filaricides/adverse effects , Humans , India/epidemiology , Longitudinal Studies , Male , Prevalence , Wuchereria bancrofti/immunology
2.
Trans R Soc Trop Med Hyg ; 98(4): 205-17, 2004 Apr.
Article in English | MEDLINE | ID: mdl-15049459

ABSTRACT

Filariasis control programmes are moving towards a strategy of repeated single-dose mass treatment of endemic populations. Using a combination, such as albendazole (ALB) to diethylcarbamazine (DEC) gives both macrofilaricidal and anti-helmintic activity. However, the safety of the combination versus DEC alone should be established in field studies in large populations prior to incorporation into national programmes. The present study compared the safety, tolerability, and efficacy of single doses of DEC 6 mg/kg + ALB placebo with DEC 6 mg/kg + ALB 400 mg in populations living in two filariasis endemic villages in the district of Wardha in western India. The study was double blind, parallel group, and randomized. Safety and tolerability study were studied in males and females older than 5 years. Safety was assessed by monitoring if adverse events (AEs) over 5 days affected daily acivities. Subjects in the 2 treatment groups experienced insignificantly different effects on daily activities and the combination was shown to be safe. Efficacy was evaluated by microfilaraemia (Mf), immunochromatographic test (ICT) and ultrasonography (USG) at 0, 3, 6, and 12 months of follow up. The efficacy study enrolled 103 male patients (aged 18-50 years) in microfilariae positive, clinical disease and asymptomatic, amicrofilaremic groups. There was no significant difference in efficacy between groups at 12 months. Within the Mf positive group, significant differences were seen in microfilaraemia (P < 0.001) with both treatments, and in USG (P < 0.001 and P < 0.004 respectively), at 12 months. The present field study has shown the combination of DEC + ALB to be as safe as the single drug DEC and thus the combination can be put in use in the national filariasis control programmes. Both drugs were adequately absorbed. The study at present does not provide evidence for the greater efficacy of the combination at 12 months follow up. While the safety of the combination has been ascertained, the incorporation or otherwise of ALB into national programmes for greater efficacy must await results of studies with longer follow up.


Subject(s)
Albendazole/administration & dosage , Diethylcarbamazine/administration & dosage , Elephantiasis, Filarial/drug therapy , Endemic Diseases , Filaricides/administration & dosage , Adolescent , Adult , Aged , Aged, 80 and over , Albendazole/adverse effects , Albendazole/blood , Child , Child, Preschool , Diethylcarbamazine/adverse effects , Diethylcarbamazine/blood , Double-Blind Method , Drug Therapy, Combination , Elephantiasis, Filarial/blood , Elephantiasis, Filarial/epidemiology , Female , Filaricides/adverse effects , Filaricides/blood , Humans , India/epidemiology , Male , Middle Aged , Treatment Outcome
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