ABSTRACT
HLA-B*35:08:17 differs from B*35:08:01:01 by a single nucleotide change in codon 105 (CCC > CCG).
Subject(s)
Genes, MHC Class I , HLA-B Antigens , Humans , Alleles , HLA-B Antigens/genetics , Codon , Nucleotides , Sequence Analysis, DNAABSTRACT
HLA-C*06:297 differs from C*06:02:01:01 by a single nucleotide change in codon-19 (CCC>TCC).
Subject(s)
HLA-C Antigens , High-Throughput Nucleotide Sequencing , Alleles , Exons/genetics , Genes, MHC Class I , HLA-C Antigens/genetics , HumansABSTRACT
HLA-B*14:58 differs from B*14:02:01 by a polymorphism at position 506 a C instead a G.
Subject(s)
Alleles , HLA-B Antigens/genetics , Base Sequence , Humans , Polymorphism, Single Nucleotide/genetics , Sequence AlignmentABSTRACT
DRB1*14:172 homologous to DRB1*14:01 has been found with a variation in 314 A > G.
Subject(s)
Alleles , Exons , HLA-DRB1 Chains/genetics , Point Mutation , Transplant Recipients , Amino Acid Substitution , Base Sequence , Codon/chemistry , HLA-DRB1 Chains/immunology , Histocompatibility Testing/methods , Humans , Liver Transplantation , Sequence Alignment , Sequence Analysis, DNAABSTRACT
HLA-A*02:548 differs from A*02:01:01:01 by one nucleotide at position 367T > C resulting in histidine at codon 99.
Subject(s)
Alleles , Amino Acid Substitution , HLA-A2 Antigen/genetics , Polymorphism, Single Nucleotide , Tissue Donors , Base Sequence , Bone Marrow Transplantation , Codon , Exons , Gene Expression , HLA-A2 Antigen/immunology , Histocompatibility Testing , Humans , Molecular Sequence Data , Sequence AlignmentABSTRACT
HLA-DRB1*03:85 differs from HLA-DRB1*03:06 by two nucleotides, position 257 A>T and position 258T>C, resulting in Valine at codon 57.
Subject(s)
Alleles , HLA-DRB1 Chains/genetics , Base Sequence , Exons/genetics , Humans , Molecular Sequence Data , Sequence AlignmentABSTRACT
BACKGROUND: Co-infection with Plasmodium falciparum malaria and Parvovirus B19 in adults is an extremely rare occurrence and, apparently, only one case has been previously reported. Herein we describe a case of acute co-infection with severe anemia and renal failure. CASE PRESENTATION: The patient was a 34-year-old African man presenting myalgia, fatigue, headache, anemia and hepatosplenomegaly. A thin peripheral smear showed Plasmodium falciparum trophozoites and the patient was treated with oral mefloquine. After an initial amelioration, fever, fatigue and myalgia reappeared, the anemia worsened and there was evidence of acute renal failure. No malarial parasites were found with a blood smear. A bone marrow aspiration showed marked erythroid hypoplasia. Parvovirus B19-specific IgM and IgG and viremia were positive. The patient was treated with steroids and blood cell transfusions. After ten days, anemia and renal failure progressively decreased. When last seen, the patient was asymptomatic and the blood values were within the normal range. CONCLUSIONS: The diagnosis of Parvovirus B19 acute infection should be considered in any case of persistent severe anemia and/or renal failure, even in clinical conditions that are well-known causes of anemia and renal failure, such as malaria.
