ABSTRACT
The identification of the metabolites of the Air Force missile fuel JP-10 was accomplished. 5-Hydroxy-JP-10 was identified as the urinary metabolite of rats, mice and hamsters exposed to JP-10. 5-Keto-JP-10 was a major metabolite found in kidney extracts of male rats exposed to JP-10 but not found in kidney extracts from female rats or from other species. Sex-related differences in the formation of 5-keto-JP-10 in rats were studied.
Subject(s)
Indans/urine , Indenes/urine , Animals , Cricetinae , Environmental Exposure , Female , Gas Chromatography-Mass Spectrometry , Male , Mice , Rats , Rats, Inbred F344ABSTRACT
The effect of JP-10, the major component of cruise missile fuel, on the development of embryonic rats was evaluated. Pregnant females were exposed via inhalation to 600 ppm or orally dosed with 250, 500 or 1000 mg JP-10/kg on gestation days 6-15. In a separate experiment both fetal and maternal blood levels of JP-10 were monitored during an inhalation exposure. Moderate signs of toxicity including tremors and convulsions were observed in the pregnant females receiving the higher doses. JP-10 was not selectively embryotoxic in the rat when administered by gavage or inhalation. Blood levels of JP-10 in the fetuses were about one half the maternal blood levels at steady state.
