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Bioorg Med Chem Lett
; 30(4): 126886, 2020 02 15.
Article
in English
| MEDLINE
| ID: mdl-31879206
ABSTRACT
Variegatic acid, isolated from Tylopilus ballouii dry fruiting bodies, is an inhibitor of ß-hexosaminidase release and tumor necrosis factor (TNF)-α secretion from rat basophilic leukemia (RBL-2H3) cells, with IC50 values of 10.4 µM and 16.8 µM, respectively. On the other hand, it inhibits PKCß1 activity with an IC50 value of 36.2 µM.