1.
Vet Pathol
; 43(1): 78-82, 2006 Jan.
Article
in English
| MEDLINE
| ID: mdl-16407493
ABSTRACT
Glanzmann thrombasthenia (GT) is an inherited, intrinsic platelet defect characterized by a quantitative or qualitative change in the platelet glycoprotein complex IIb-IIIa (integrin alpha(IIb)beta3). The subunits are encoded by separate genes and both subunits must be expressed for a stable complex to form on the platelet surface; therefore, a defect in either gene can result in GT.