ABSTRACT
Torrubiellone E (1), a new N-hydroxypyridone alkaloid, was isolated from the spider pathogenic fungus Torrubiella longissima BCC 2022, together with the known compounds, torrubiellones A (2) and B (3), and JBIR-130 (4). Compound 1 exhibited antimalarial activity against Plasmodium falciparum K1 with an IC5 value of 3.2 microg/mL, while it also showed weak cytotoxic activities.
Subject(s)
Alkaloids/isolation & purification , Antimalarials/isolation & purification , Hypocreales/chemistry , Pyridones/isolation & purification , Spiders/microbiology , Alkaloids/pharmacology , Animals , Antimalarials/pharmacology , Cell Line, Tumor , Humans , Plasmodium falciparum/drug effects , Pyridones/pharmacologyABSTRACT
New spirocyclic and bicyclic hemiacetals, isariotins E (1) and F (2), together with TK-57-164A (3) were isolated from the entomopathogenic fungus Isaria tenuipes BCC 12625. The absolute configuration of 3 was addressed by application of the modified Mosher's method. Isariotin F (2) exhibited activity against the malaria parasite Plasmodium falciparum K1 with an IC(50) value of 5.1 microM and cytotoxic activities against cancer cell lines (KB, BC, and NCI-H187) and nonmalignant (Vero) cells with respective IC(50) values of 15.8, 2.4, 1.6, and 2.9 microM.
Subject(s)
Antimalarials/isolation & purification , Antitubercular Agents/isolation & purification , Bridged Bicyclo Compounds, Heterocyclic/isolation & purification , Epoxy Compounds/isolation & purification , Heterocyclic Compounds, Bridged-Ring/isolation & purification , Hypocreales/chemistry , Plasmodium falciparum/drug effects , Spiro Compounds/isolation & purification , Animals , Antimalarials/chemistry , Antimalarials/pharmacology , Antineoplastic Agents/chemistry , Antineoplastic Agents/isolation & purification , Antineoplastic Agents/pharmacology , Antitubercular Agents/chemistry , Antitubercular Agents/pharmacology , Bridged Bicyclo Compounds, Heterocyclic/chemistry , Bridged Bicyclo Compounds, Heterocyclic/pharmacology , Candida albicans/drug effects , Chlorocebus aethiops , Drug Screening Assays, Antitumor , Epoxy Compounds/chemistry , Heterocyclic Compounds, Bridged-Ring/chemistry , Humans , Inhibitory Concentration 50 , Molecular Structure , Mycobacterium tuberculosis/drug effects , Parasitic Sensitivity Tests , Spiro Compounds/chemistry , Spiro Compounds/pharmacology , Thailand , Vero CellsABSTRACT
Two novel diphenyl ether glycosides and a new diphenyl ether, cordyol A-C (1-3), were isolated from the insect pathogenic fungus Cordyceps sp. BCC 1861. Structures of these compounds were elucidated by NMR and MS spectral analyses. Cordyol C (3) exhibited significant anti-HSV-1 activity with an IC50 value of 1.3 microg/ml, and cytotoxic activity against BC and NCI-H187 cancer cell lines with IC50 values of 8.65 and 3.72 microg/ml, respectively. Cordyol A (1) displayed weak antimycobacterial activity with a MIC value of 100 microg/ml.
Subject(s)
Anti-Bacterial Agents/pharmacology , Antineoplastic Agents/pharmacology , Cordyceps/chemistry , Insecta/microbiology , Phenyl Ethers/pharmacology , Animals , Cell Line, Tumor , Cordyceps/pathogenicity , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Mass Spectrometry , Microbial Sensitivity Tests , Molecular Structure , Phenyl Ethers/chemistry , Phenyl Ethers/isolation & purificationABSTRACT
A new cycloheptapeptide, cordyheptapeptide A (1), was isolated from the insect pathogenic fungus Cordyceps sp. BCC 1788 along with four known bioxanthracenes (2-5). The structure was elucidated by spectroscopic data. The absolute configuration of amino acid residues was determined by HPLC and X-ray diffraction analyses.
