Subject(s)
Adenomyoepithelioma/diagnostic imaging , Breast Neoplasms/diagnostic imaging , Neoplasms, Multiple Primary/diagnostic imaging , Adenomyoepithelioma/diagnosis , Adenomyoepithelioma/surgery , Adult , Biopsy, Fine-Needle , Breast Neoplasms/diagnosis , Breast Neoplasms/surgery , Diagnosis, Differential , Female , Humans , Mammography , Neoplasms, Multiple Primary/diagnosis , Neoplasms, Multiple Primary/surgery , Ultrasonography, MammaryABSTRACT
A 71-year-old white male presented to the emergency department complaining of a worsening lower extremity rash. Thirteen days before presentation, the patient was placed on Multaq (dronedarone) for his paroxysmal atrial fibrillation. Biopsy-proven leukocytoclastic vasculitis (LV) was diagnosed, and causes for the condition other than drug-induced were investigated and ruled out. Rash has been cited as a possible side effect of Multaq; however, a literature search has revealed this to be the first documented case of likely multaq-induced LV. Other patients on Multaq therapy should be monitored for signs and symptoms of LV and be referred to an acute care setting as indicated.
Subject(s)
Amiodarone/analogs & derivatives , Anti-Arrhythmia Agents/adverse effects , Vasculitis, Leukocytoclastic, Cutaneous/chemically induced , Aged , Amiodarone/adverse effects , Amiodarone/therapeutic use , Anti-Arrhythmia Agents/therapeutic use , Atrial Fibrillation/drug therapy , Biopsy , Dronedarone , Humans , Lower Extremity , Male , Vasculitis, Leukocytoclastic, Cutaneous/pathologyABSTRACT
After presenting for a routine screening exam, and 57-year-old man was diagnosed with an incidentaloma-a primitive neuroectodermal tumor (PNET) of the thymus. A member of the Ewing sarcoma family of tumors, a PNET is typically regarded as a malignancy of childhood and adolescence, usually occurring in the central nervous system. In the case at hand, our patient had an extremely unusual presentation, given his age and tumor location. Initial presentation is the only predictor for long-term survival. Current treatment recommendations advocate complete surgical resection whenever possible, radiation therapy, and adjuvant versus neoadjuvant chemotherapy.
