ABSTRACT
The efficacy of human leukocytic interferon (ointment), 20000 IU/g, in the treatment of viral diseases of the buccal mucosa was studied in 152 patients. The results were compared with those achieved with the commercial antiviral agent 0.5% oxolin ointment. The results evidence a manifest antiviral effect of the interferon ointment, recommending it for practical dentistry.
Subject(s)
Antiviral Agents/therapeutic use , Stomatitis, Herpetic/drug therapy , Adult , Drug Evaluation , Humans , Interferon-alpha/administration & dosage , Mouth Mucosa , Ointments , Recurrence , Remission Induction , Tetrahydronaphthalenes/administration & dosage , Time FactorsABSTRACT
Clinical efficacies of ointments containing alpha- and gamma-interferon and characterized by antiviral activity (2.0 x 10(4) IU) were studied. Antiviral effect of these ointments used in the treatment of 168 children suffering from herpetic stomatitis was assessed from the clinical and immunologic viewpoints. Measurements of secretory IgG carried out over the course of therapy evidenced positive changes in local immunity.
Subject(s)
Interferon Type I/administration & dosage , Interferon-gamma/administration & dosage , Stomatitis, Herpetic/therapy , Acute Disease , Child , Child, Preschool , Drug Evaluation , Humans , Immunoglobulin A, Secretory/analysis , Infant , Ointments , Recurrence , Saliva/immunology , Stomatitis, Herpetic/immunologyABSTRACT
Interferon was injected intracervically as the first stage of combination treatment in 125 cases of histologically verified squamous Ca in situ and invasive cervical carcinoma. Colpomicroscopic, cytological and histological examination was carried out before and after treatment. The pronounced effect of interferon as an antitumor agent was established. Post-treatment histological examination failed to detect any tumor cells in 36 out of 125 patients (28.8%). Widening the scope of indications for preservative operations in patients with preinvasive and microinvasive cervical carcinoma after preliminary interferon therapy was suggested.
Subject(s)
Carcinoma in Situ/therapy , Carcinoma, Squamous Cell/therapy , Interferons/therapeutic use , Uterine Cervical Neoplasms/therapy , Carcinoma in Situ/pathology , Carcinoma, Squamous Cell/pathology , Cell Nucleus/pathology , Cytoplasm/pathology , Female , Humans , Microscopy, Fluorescence , Uterine Cervical Neoplasms/pathologyABSTRACT
Conditions for and regularities of gamma-interferon production were elucidated. High interferon inducing activity of the known inductors such as concanavalin A, phytohemagglutinin and lentil lectin was asserted. It was shown that aqueous and alcoholic extracts of legumes seeds were also able to induce interferon synthesis in cultures of human peripheral blood leukocytes. By physicochemical properties such as stability to acids and liability to heating and by antigenic properties, interferon produced under such conditions was of type 2 (gamma). The maximum yield of interferon was observed in stationary and roller leukocyte cultures at a density of 2.10(6)-4.10(6) cells/ml on commercial rich media (IMDM and Eagle medium). Dynamics of gamma-interferon biosynthesis was determined. The peak of interferon production after the leukocyte induction with plant lectins was recorded in 72-96 hours.
