ABSTRACT
BACKGROUND: Prosthetic breast reconstruction is critical in the radiated breast. The main purpose of this study was to determine whether fat grafting prior to breast reconstruction could improve thoracic tissue trophicity enough to perform a simple prosthetic reconstruction, avoiding a flap procedure. PATIENTS AND METHODS: A total of 25 patients who had undergone a modified radical mastectomy followed by radiotherapy were retrieved. Fat was injected according to Coleman's technique. Prosthetic reconstruction was performed three to six months after the fat grafting procedure. Reconstruction of the nipple-areola complex was performed 3 months after implant positioning. Median follow-up interval was two years. Patient satisfaction was ascertained with a self-assessment questionnaire. Three independent blinded physician observers judged preoperative and postoperative photographs to determine the quality of reconstruction. RESULTS: The mean refined fat injected volume was 160ml. In all cases except two, a unique fat grafting procedure was necessary. Prosthetic reconstruction was achieved in 23 cases. The technique failed in two cases and breast reconstruction was achieved by a latissimus dorsi flap with implant. During the follow-up interval, two complications occurred in two patients presenting with fat necrosis and oil cysts. The mean number of total surgical procedures was 2.5 per patient. Quality of reconstruction was judged as good by both physicians and patients. CONCLUSIONS: Autologous fat grafting in radiated tissue prior to breast reconstruction is a safe and reliable technique. In selected cases, a simple prosthetic reconstruction can be achieved avoiding a flap procedure.
Subject(s)
Adipose Tissue/transplantation , Breast Implants , Breast/radiation effects , Mammaplasty/methods , Mastectomy, Modified Radical/adverse effects , Adult , Aged , Breast Neoplasms/radiotherapy , Breast Neoplasms/surgery , Female , Humans , Middle Aged , Patient Satisfaction , Radiotherapy, Adjuvant/adverse effects , Reproducibility of Results , Retrospective Studies , Surveys and Questionnaires , Transplantation, Autologous , Treatment OutcomeABSTRACT
BACKGROUND: Following kidney transplantation, ischemia-reperfusion injury contributes to adverse outcomes. The purpose of this study was to determine whether a cold-storage solution saturated with noble gas (xenon or argon) could limit ischemia-reperfusion injury following cold ischemia. METHODS: Sixty Wistar rats were randomly allocated to 4 experimental groups. Kidneys were harvested and then stored for 6 h before transplantation in cold-storage solution (Celsior®) saturated with either air, nitrogen, xenon or argon. A syngenic orthotopic transplantation was performed. Renal function was determined on days 7 and 14 after transplantation. Transplanted kidneys were removed on day 14 for histological and immunohistochemical analyses. RESULTS: Creatinine clearance was significantly higher and urinary albumin significantly lower in the argon and xenon groups than in the other groups at days 7 and 14. These effects were considerably more pronounced for argon than for xenon. In addition, kidneys stored with argon, and to a lesser extent those stored with xenon, displayed preserved renal architecture as well as higher CD-10 and little active caspase-3 expression compared to other groups. CONCLUSION: Argon- or xenon-satured cold-storage solution preserved renal architecture and function following transplantation by reducing ischemia-reperfusion injury.
ABSTRACT
Mirror hand is a rare congenital deformity of the upper limb which is characterized by duplication of the ulna (ulnar dimelia), absence of the radius and polydactyly. The authors report a case of ulnar dimelia with treatment of the of the elbow stiffness by surgery and splinting, and the flexed radial club hand deformity of the wrist solely by early splinting. This treatment was performed both before and after pollicization which was performed at 12 months. The stiffness of the elbow and wrist is very difficult to treat and remains a major problem whereas pollicization is now an established and successful means of treating the hand deformity.
