ABSTRACT
The purpose of this study was to examine psychomotor development in children born to mothers with type 1 diabetes mellitus (DM1) or gestational diabetes mellitus (GDM). The influence of metabolic control in pregnant diabetic mothers and complications during labor on their children's psychological and physical development was evaluated. The analysis included 59 children, 20 of mothers with GDM, 19 of mothers with DM1, and 20 children of healthy mothers. Clinical observations and medical history were recorded and children were assessed using the Brunet-Lezine Psychomotor Development Scale. Abnormalities were found more often in the children of mothers with DM1 whose illness was insufficiently controlled during pregnancy and of mothers with serious hypoglycemia while pregnant. Speech, eye-movement coordination and social aspects were affected.
Subject(s)
Child Development/physiology , Diabetes Mellitus, Type 1/psychology , Diabetes, Gestational/psychology , Psychomotor Performance/physiology , Adult , Child, Preschool , Eye Movements/physiology , Female , Humans , Infant , Infant, Newborn , Locomotion/physiology , Posture/physiology , Pregnancy , Social Behavior , Speech/physiologyABSTRACT
UNLABELLED: Aim of the study was early diagnosis of CNS damage and dysfunction in the progeny of women with diabetes type 1 (DM1). Interdependencies between the course of diabetes in mothers and fetal-perinatal complications and neurological state of the progeny were also analysed. 35 children of mothers with DM1 and 109 in control group underwent neurological examinations at the age of 3, 6, 9, 12 and 18 months. RESULTS: In the group of children of DM1 mothers four had symptoms of CNS damage such as cerebral palsy or psychomotor delay. In the remaining 9 children so-called "soft" neurological signs or minor neurological dysfunction were found. In control group 1 had a light form of cerebral palsy and 3 had symptoms of minor neurological dysfunction. The dependencies of frequency and gravity of neurological disorders in children on diabetes metabolic control and complications and hypoxemic-ischemic states, prematurity, macrosomia and hypoglycemia in newborns was observed. CONCLUSION: The symptoms of CNS dysfunctions are more frequent and more serious in children of DM1 mothers than in control group.
Subject(s)
Central Nervous System Diseases/diagnosis , Developmental Disabilities/diagnosis , Diabetes Mellitus, Type 1 , Pregnancy Complications , Adolescent , Adult , Child , Child, Preschool , Female , Humans , Neurologic Examination , Pregnancy , Prospective StudiesABSTRACT
The purpose of the study was comparison of the therapeutic results in epileptic children receiving one or more drugs. The study was carried out in a group of 93 epileptic children divided into two groups receiving monotherapy or polytherapy. These two groups were compared with respect to the age of epilepsy development, type of epileptic seizures and coexistence of neurological disturbances. It was found that monotherapy was possible in about 70% of cases, and therapeutic failures in monotherapy occurred mostly in children with symptomatic epilepsy beginning at a relatively young age and manifesting itself with more than one type of seizures.
