ABSTRACT
PURPOSE: Anal canal adenocarcinoma (AC) is rare and its surgical outcomes and prognostic factors (PFs) are not well understood. The aim of this retrospective study was to identify the characteristics and PFs of AC, using population-based data in Japan. METHODS: Patients with AC (n = 390) or lower rectal adenocarcinoma (LR) (n = 12,477) diagnosed between1991 and 2006 were enrolled in this study. We compared the clinical- and patient-related factors of the two diseases and then examined propensity score matching, overall survival (OS), and PFs. RESULTS: AC tended to develop more often in women and in patients of advanced age. Macroscopically, AC was of an unclassified type and microscopically, it was of high-grade histological types such as mucinous adenocarcinoma, poorly differentiated adenocarcinoma (por), or signet-ring cell carcinoma (sig), with a high frequency of inguinal node metastasis (P < 0.05). The 5 year OS rates were 56.9% for AC and 67.9% for LR (P = 0.002). The PFs of AC were a high-grade histological type (por/sig), T, N, and M. CONCLUSIONS: AC has a significantly worse prognosis than LR. Moreover, the AC lymph node metastatic sites for AC, especially the inguinal nodes, are different from those for LR.
Subject(s)
Adenocarcinoma , Anal Canal , Adenocarcinoma/pathology , Anal Canal/pathology , Female , Humans , Japan/epidemiology , Neoplasm Staging , Prognosis , Propensity Score , Retrospective StudiesABSTRACT
No disponible
Subject(s)
Humans , Female , Young Adult , Neurilemmoma/diagnostic imaging , Jejunal Neoplasms/diagnostic imaging , Capsule Endoscopy/methods , Neurilemmoma/pathology , Jejunal Neoplasms/pathologyABSTRACT
We present a rare case of a 60-year-old woman with jejunal schwannoma. This is the first case of intestinal schwannomas detected by video capsule endoscopy. Characteristic endoscopic and immunohistochemical pictures are presented with a brief literature review.
Subject(s)
Capsule Endoscopy , Neurilemmoma , Female , Humans , Jejunum/diagnostic imaging , Jejunum/surgery , Middle Aged , Neurilemmoma/diagnostic imaging , Neurilemmoma/surgeryABSTRACT
PURPOSE: Propiverine hydrochloride (PH) is widely used for the treatment of urinary incontinence (UI) due to bladder overactivity. Moreover, the comorbidity of UI with fecal incontinence (FI) is known to be due to the relationship of both to nervous system disorders and dysfunction or weakening of the pelvic floor muscles. The aim of this single-arm prospective study was to evaluate the therapeutic value of PH for FI. METHODS: Patients (n = 24) who were diagnosed as having both FI and UI from April 2015 to November 2016 were included in the study and administered a dosage of 10-20 mg PH every day for 1 month. The primary endpoint was to create a reduction in the frequency of FI per week. An evaluation criterion of ≥50% reduction in frequency was determined as effective. The percentage of the patients who achieved the ≥50% endpoint (responders) was also calculated. RESULTS: The frequency of FI per week was 6.0 ± 8.2 (0.25-30) at baseline and reduced to 1.6 ± 2.1 (0-7) at the posttherapeutic state (P = 0.005). A reduction of ≥50% was seen in 14 of the patients (58.3%). CONCLUSION: PH reduced the frequency of FI in patients with both FI and UI. This study introduces a possible therapeutic option for the pharmacological treatment of FI.
ABSTRACT
An 84-year-old man had the wall thickness of his stomach accidentally detected by CT scan, and was diagnosed as type 2 advanced gastric cancer with liver and lung metastasis. Chemotherapy with docetaxel, cisplatin and S-1 combination therapy was adopted. Grade 4 neutropenia was revealed, but the treatment could be continued by G-CSF or by down dosing the anticancer agents. By maintaining CR of the primary lesion and PR of the liver and lung metastases, he has been kept at a PS 0 state and has been receiving regular outpatient treatment for 28 months now since the beginning of treatment.
