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1.
Rev Fac Cien Med Univ Nac Cordoba ; 62(2 Suppl 1): 37-47, 2005.
Article in Spanish | MEDLINE | ID: mdl-16972742

ABSTRACT

It has been seen an increase of the cervical cancer and of intraepithelial cancer in the last years. The most important risk factors for cervical cancer are sexual conduct, early of sexual relationships, number of partners, cigarettes, oral anticonceptive, pregnancy, immunosuppression, sexually transmitted illness. And an important role of the Human Papilloma Virus. The HPV has been classified in 3 groups; low risk, the most frequents are 11 and 6, middle risk, tipe 31, 33 and 35, and high risk, 16 and 18, that have frequent association with cervical cancer and with high grade intraepithelial lesions. The cervicovaginal citology is still the most accurate diagnosis method to detect SIL or CIN and invasive cancer in early stages, it is discussed the periodicity and group of women to whom the method must point. There are different options depending if it is a SIL of low or high grade or and cancer. With the possibility of doing follow up or treatment, such as. LLETZ, Laser, Criotraphy, cone and interferon for the preneoplastic lesions. The achievement of a vaccine for HPV could have a significant impact on these pathology.


Subject(s)
Papillomaviridae , Papillomavirus Infections/complications , Uterine Cervical Dysplasia , Uterine Cervical Neoplasms , Female , Humans , Incidence , Papillomavirus Vaccines , Risk Factors
3.
Rev. Fac. Cienc. Méd. (Córdoba) ; 62(2,supl. 1): 37-47, 2005. tab
Article in Spanish | BINACIS | ID: bin-123373

ABSTRACT

Se ha observado en los últimos años un incremento del carcinoma del cuello uterino de neoplasia intraepitelial cervical,. Los factores de riesgo más importantes para el cáncer de cerviz son el inicio precoz, de las relaciones sexuales, el número de parejas sexuales, el tabaco, los anticonceptivos orales, paridad, estados de inmunosu-presión, y enfermedades de transmisión sexual. Igual-mente, se ha demostrado el importante papel del virus del papiloma humano. Se han clasificado en tres grupos de VPH: de bajo riesgo, tipos 6 y 11; de mediano riesgo, tipos 31, 33 Y 35 Y de alto riesgo, los mas frecuentemente encontrados son tipos 16 y 18, que presentan frecuente asociación con el cáncer del cuello uterino y con las lesiones intraepiteliales de alto grado. La citología cervicovaginal sigue siendo el método diagnóstico de mayor valor para detectar la neoplasia intracervical cervical(CIN) o lesiones escamosas (SIL) y el carcinoma invasivo estadios precoces, discutiéndose la periodicidad y el grupo de mujeres al cual debe apuntar este método. Existen diferentes conductas de acuerdo a si se trata de SIL de bajo o alto grado o carcinoma invasor. Con la posibilidad de realizar controlo tratamiento; como, vaporización con láser, asa diatérmica (LLETZ), crioterapia, conización y actualmente en estudio tratamiento médico con los retinoides, el 5-fluoro-uracilo e interferones para el tratamiento de las lesiones preneoplasicas. La creación de una vacuna contra el HPV podría tener un significativo impacto sobre esta patología.(AU)


It has been seen an increase of the cervical cancer and of intraephitlial cancer in the last years. The most important risk factors for cervix cancer are sexual conduct, early of sexual relationships. number of partners, cigarettes, oral anticonceptive, pregnancy, Inmunosupresion, sexually transmitted illness. And an important role of the Human Papiloma Virus. The HPV has been classified in 3 groups; low risk, the most frequents are II and 6, middle risk, type 31. 33 and 35. and high risk, 16 and 18, that have frequent association with cervical cancer and with high grade intraephitlial lesions. The cervicovaginal cytology is still the most accurate diagnosis method to detect SIL or CIN and invasive cancer in early stages, it is discussed the periodicity and group of women to whom the method must point. There are different options depending if it is a SIL of low or high grade or and cancer. With the possibility of doing follow up or treatment, such as. LLETZ, Laser, Criotraphy, cone and interferon for the preneoplastic lessons. The achievement of a vaccine for HPV could have a significant impact on this pathology.(AU)


Subject(s)
Humans , Female , Uterine Cervical Neoplasms/prevention & control , Papillomavirus Infections/complications , Uterine Cervical Dysplasia/prevention & control , Papillomaviridae , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/virology , Papillomavirus Infections/therapy , Uterine Cervical Dysplasia/pathology , Uterine Cervical Dysplasia/virology , Risk Factors , Viral Vaccines
4.
Rev. Fac. Cienc. Méd. (Córdoba) ; 62(2,supl. 1): 37-47, 2005. tab
Article in Spanish | LILACS | ID: lil-441200

ABSTRACT

Se ha observado en los últimos años un incremento del carcinoma del cuello uterino de neoplasia intraepitelial cervical,. Los factores de riesgo más importantes para el cáncer de cerviz son el inicio precoz, de las relaciones sexuales, el número de parejas sexuales, el tabaco, los anticonceptivos orales, paridad, estados de inmunosu-presión, y enfermedades de transmisión sexual. Igual-mente, se ha demostrado el importante papel del virus del papiloma humano. Se han clasificado en tres grupos de VPH: de bajo riesgo, tipos 6 y 11; de mediano riesgo, tipos 31, 33 Y 35 Y de alto riesgo, los mas frecuentemente encontrados son tipos 16 y 18, que presentan frecuente asociación con el cáncer del cuello uterino y con las lesiones intraepiteliales de alto grado. La citología cervicovaginal sigue siendo el método diagnóstico de mayor valor para detectar la neoplasia intracervical cervical(CIN) o lesiones escamosas (SIL) y el carcinoma invasivo estadios precoces, discutiéndose la periodicidad y el grupo de mujeres al cual debe apuntar este método. Existen diferentes conductas de acuerdo a si se trata de SIL de bajo o alto grado o carcinoma invasor. Con la posibilidad de realizar controlo tratamiento; como, vaporización con láser, asa diatérmica (LLETZ), crioterapia, conización y actualmente en estudio tratamiento médico con los retinoides, el 5-fluoro-uracilo e interferones para el tratamiento de las lesiones preneoplasicas. La creación de una vacuna contra el HPV podría tener un significativo impacto sobre esta patología.


It has been seen an increase of the cervical cancer and of intraephitlial cancer in the last years. The most important risk factors for cervix cancer are sexual conduct, early of sexual relationships. number of partners, cigarettes, oral anticonceptive, pregnancy, Inmunosupresion, sexually transmitted illness. And an important role of the Human Papiloma Virus. The HPV has been classified in 3 groups; low risk, the most frequents are II and 6, middle risk, type 31. 33 and 35. and high risk, 16 and 18, that have frequent association with cervical cancer and with high grade 'intraephitlial lesions. The cervicovaginal cytology is still the most accurate diagnosis method to detect SIL or CIN and invasive cancer in early stages, it is discussed the periodicity and group of women to whom the method must point. There are different options depending if it is a SIL of low or high grade or and cancer. With the possibility of doing follow up or treatment, such as. LLETZ, Laser, Criotraphy, cone and interferon for the preneoplastic lessons. The achievement of a vaccine for HPV could have a significant impact on this pathology.


Subject(s)
Humans , Female , Uterine Cervical Dysplasia/prevention & control , Papillomaviridae , Papillomavirus Infections/complications , Uterine Cervical Neoplasms/prevention & control , Uterine Cervical Dysplasia/pathology , Uterine Cervical Dysplasia/virology , Papillomavirus Infections/therapy , Risk Factors , Uterine Cervical Neoplasms/pathology , Uterine Cervical Neoplasms/virology , Viral Vaccines
6.
Int J Clin Pharmacol Res ; 21(1): 31-41, 2001.
Article in English | MEDLINE | ID: mdl-11708573

ABSTRACT

This randomized, double-blind, multicenter placebo-controlled study was conducted to investigate the efficacy and tolerability of policosanol, a cholesterol-lowering drug purified from sugar cane wax, in women who had experienced menopause and showed elevated serum total cholesterol and low density lipoprotein (LDL)-cholesterol levels despite a 6-week standard lipid-lowering diet. Thus, 56 eligible patients were randomized to receive placebo or policosanol 5 mg/day for 8 weeks and the dose was doubled to 10 mg/day during the next 8 weeks. Policosanol (5 and 10 mg/day) significantly decreased LDL-cholesterol (17.3% and 26.7%, respectively), total cholesterol (12.9% and 19.5%) as well as the ratios of LDL-cholesterol to high-density lipoprotein (HDL)-cholesterol (17.2% and 26.5%) and total cholesterol to HDL-cholesterol (16.3% and 21.0%) compared with baseline and placebo. HDL-cholesterol levels were significantly raised by 7.4% at study completion. No significant changes occurred in the lipid profile of the placebo group. The drug was safe and well tolerated. No drug-related adverse effects were observed. None of the patients administered policosanol but three of those administered placebo withdrew from the trial because of adverse effects: one due to a serious hypertensive status, one because of an allergic reaction (pruritus plus skin rash) and one due to gastrointestinal disturbances (nauseas plus vomiting). Eleven placebo patients reported 24 adverse effects compared with six policosanol patients who reported seven adverse effects (p < 0.05). In addition, five placebo (17.9%) and 13 policosanol patients (46.4%) (p < 0.05) reported improvements in habitual symptoms and health perception during the study. In conclusion, policosanol was effective and well tolerated in hypercholesterolemic postmenopausal women, showing additional benefits in the health perception of the study patients.


Subject(s)
Anticholesteremic Agents/therapeutic use , Fatty Alcohols/therapeutic use , Hypercholesterolemia/drug therapy , Postmenopause/physiology , Anticholesteremic Agents/adverse effects , Cholesterol/blood , Cholesterol, HDL/blood , Cholesterol, LDL/blood , Double-Blind Method , Fatty Alcohols/adverse effects , Female , Humans , Hypercholesterolemia/blood , Middle Aged
7.
Reproducción ; 15(4): 183-5, dic. 2000. ilus
Article in Spanish | BINACIS | ID: bin-9601

ABSTRACT

Introducción: Chlamydia trachomatis es causa frecuente de enfermedad inflamatoria pélvica y esterilidad tubaria. La afección endometrial asociada a este germen es dificil de poner de manifiesto. La úteroglobina (Utgh) es una proteína de secreción del tracto respiratorio y genitourinario. En el endometrio se ha detectado durante el comienzo y mitad de la fase selectora. Nuestro objetivo fue localizar la Utgb endometrial por inmunohistoquímica, en pacientes que consultaron por esterilidad y presentaron serología positiva contra C. trachomatis. Material y Metodos: Se estudiaron 30 parejas a las que se les realizó: análisis de esperma, dosajes hormonales, histerosalpingografía, anticuerpos séricos contra C.trachomatis (IgG Cht) y biopsia endometrial (días 19-21 del ciclo). En las biopsias se determinó fechado y presencia de endometritis. La inmunohistoquímica para Utgb se realizó en cortes de parafina usando antisuero policlonal (1:50 y 1:300). Resultados: De las muestras evaluadas, 20 presentaron fechado endometrial acorde al día del prelevamiento (día 19-21). La inmunomarcación para Utgb, fue positiva en el 100 por ciento (20/20) de los casos, con la dilución de anticuerpo 1:50. Se encontró título de IgG Ch t incrementando en 11 pacientes (11/20, 55 por ciento). El 91 por ciento (10/11) de estas presentaron inmunomarcación para Utgb, mientras que el grupo con serología negativa, se detectó en el 44,5 por ciento (4/9) cuando se empleó la dilución 1:300 (p<0.02). La incidencia de endometritis y los niveles de progesterona sérica no mostraron diferencias significativas entre estos grupos. Conclusión: Hemos observado una mayor incidencia de afección endometrial en pacientes con serología positiva para C trachomatis. La inmunodetección de uteroglobina podría ser un marcador de dicha afección, que complementaría la información obtenida por microscopía óptica (AU)


Subject(s)
Humans , Male , Female , Uteroglobin/diagnosis , Chlamydia Infections/diagnosis , Chlamydia Infections/complications , Infertility, Female/etiology , Pelvic Inflammatory Disease/etiology , Endometritis/etiology , Endometrium/pathology
8.
Reproducción ; 15(4): 183-5, dic. 2000. ilus
Article in Spanish | LILACS | ID: lil-294579

ABSTRACT

Introducción: Chlamydia trachomatis es causa frecuente de enfermedad inflamatoria pélvica y esterilidad tubaria. La afección endometrial asociada a este germen es dificil de poner de manifiesto. La úteroglobina (Utgh) es una proteína de secreción del tracto respiratorio y genitourinario. En el endometrio se ha detectado durante el comienzo y mitad de la fase selectora. Nuestro objetivo fue localizar la Utgb endometrial por inmunohistoquímica, en pacientes que consultaron por esterilidad y presentaron serología positiva contra C. trachomatis. Material y Metodos: Se estudiaron 30 parejas a las que se les realizó: análisis de esperma, dosajes hormonales, histerosalpingografía, anticuerpos séricos contra C.trachomatis (IgG Cht) y biopsia endometrial (días 19-21 del ciclo). En las biopsias se determinó fechado y presencia de endometritis. La inmunohistoquímica para Utgb se realizó en cortes de parafina usando antisuero policlonal (1:50 y 1:300). Resultados: De las muestras evaluadas, 20 presentaron fechado endometrial acorde al día del prelevamiento (día 19-21). La inmunomarcación para Utgb, fue positiva en el 100 por ciento (20/20) de los casos, con la dilución de anticuerpo 1:50. Se encontró título de IgG Ch t incrementando en 11 pacientes (11/20, 55 por ciento). El 91 por ciento (10/11) de estas presentaron inmunomarcación para Utgb, mientras que el grupo con serología negativa, se detectó en el 44,5 por ciento (4/9) cuando se empleó la dilución 1:300 (p<0.02). La incidencia de endometritis y los niveles de progesterona sérica no mostraron diferencias significativas entre estos grupos. Conclusión: Hemos observado una mayor incidencia de afección endometrial en pacientes con serología positiva para C trachomatis. La inmunodetección de uteroglobina podría ser un marcador de dicha afección, que complementaría la información obtenida por microscopía óptica


Subject(s)
Humans , Male , Female , Chlamydia Infections/diagnosis , Uteroglobin , Chlamydia Infections/complications , Endometritis/etiology , Endometrium/pathology , Infertility, Female/etiology , Pelvic Inflammatory Disease/etiology
9.
Obstet. ginecol. latinoam ; 55(1): 8-12, 1997. tab
Article in Spanish | BINACIS | ID: bin-14468

ABSTRACT

El objetivo de esta investigación es definir el perfil del consumo de medicamentos durante el primer trimesstre del embarazo y detectar el uso de potenciales teratógenos(AU)


Subject(s)
Humans , Female , Middle Aged , Uterine Cervical Dysplasia/surgery , Uterine Cervical Dysplasia/pathology , Gynecologic Surgical Procedures , Argentina
10.
Obstet. ginecol. latinoam ; 55(1): 8-12, 1997. tab
Article in Spanish | LILACS | ID: lil-247573

ABSTRACT

El objetivo de esta investigación es definir el perfil del consumo de medicamentos durante el primer trimesstre del embarazo y detectar el uso de potenciales teratógenos


Subject(s)
Humans , Female , Middle Aged , Argentina , Uterine Cervical Dysplasia/pathology , Uterine Cervical Dysplasia/surgery , Gynecologic Surgical Procedures
11.
Article in Spanish | MEDLINE | ID: mdl-8560064

ABSTRACT

Our experience is based on laparoscopic hysterectomies performs from August 1992 to May 1994. The purpose of the initial surgical objective is described, as well as different variations of the technique. The procedure was systematized, the operating time was diminished to a considerable extent, thus avoiding intra-operatory complications. Pre-operatory diagnosis and histopathological findings were enumerated. Intra-operatory and post-operatory complications were evaluated. With an increasing development of the technique, a shorter operating time was made possible. The length of hospital stay and its quality were unrelated to the operation time. A quick recovery was reached as regards complete activity of the patients. Laparoscopic hysterectomy performed by an endoscopic-gynecologist surgeon represents an alternative and a new way of thinking.


Subject(s)
Hysterectomy/methods , Laparoscopy , Adult , Age Factors , Aged , Female , Humans , Hysterectomy/adverse effects , Length of Stay/economics , Middle Aged
12.
Article in Spanish | BINACIS | ID: bin-37339

ABSTRACT

Our experience is based on laparoscopic hysterectomies performs from August 1992 to May 1994. The purpose of the initial surgical objective is described, as well as different variations of the technique. The procedure was systematized, the operating time was diminished to a considerable extent, thus avoiding intra-operatory complications. Pre-operatory diagnosis and histopathological findings were enumerated. Intra-operatory and post-operatory complications were evaluated. With an increasing development of the technique, a shorter operating time was made possible. The length of hospital stay and its quality were unrelated to the operation time. A quick recovery was reached as regards complete activity of the patients. Laparoscopic hysterectomy performed by an endoscopic-gynecologist surgeon represents an alternative and a new way of thinking.

14.
Minerva Med ; 74(1-2): 25-9, 1983 Jan 14.
Article in Italian | MEDLINE | ID: mdl-6218429

ABSTRACT

The part played by 99Tc liver scintiscanning and laparoscopy, singly or sequentially, in the diagnosis of hepatic nodular disease was examined in a series of 316 patients. It was found that sequential employment of these two methods constituted a good diagnostic approach, since the relative sensitivity of the first could be added to the relative specificity of the second.


Subject(s)
Liver Diseases/diagnostic imaging , Liver Diseases/diagnosis , Cysts/diagnosis , Hepatitis/diagnosis , Humans , Laparoscopy , Liver Neoplasms/diagnosis , Liver Neoplasms/secondary , Radionuclide Imaging , Sulfur , Technetium , Technetium Tc 99m Sulfur Colloid
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