Subject(s)
Psoriasis , Humans , Leucine , Biomarkers , Chronic Disease , Acute Disease , GlycoproteinsABSTRACT
Abstract A 41-year-old female visited our department complaining of asymptomatic subcutaneous nodules on the right forearm. She had been diagnosed as having Cushing syndrome due to an adrenal tumor 5-months previously. After she underwent surgery for the adrenal tumor, the subcutaneous nodules gradually increased in number. Physical examination showed ill-defined plate-like subcutaneous indurations on the bilateral lower extremities, buttocks, and right forearm. A biopsy of one of the subcutaneous indurations showed non-caseating epithelioid cell granulomas involving the hypodermis and subcutaneous tissues. The patient was diagnosed as having sarcoidosis based on the Japan Society of Sarcoidosis and Other Granulomatous Disorders 2015 criteria. Skin lesions decreased in size and had completely disappeared. Although the mechanism is unknown, there may be a possibility that the activity of sarcoidosis is suppressed by high cortisol concentrations due to Cushing syndrome.
ABSTRACT
A 41-year-old female visited our department complaining of asymptomatic subcutaneous nodules on the right forearm. She had been diagnosed as having Cushing syndrome due to an adrenal tumor 5-months previously. After she underwent surgery for the adrenal tumor, the subcutaneous nodules gradually increased in number. Physical examination showed ill-defined plate-like subcutaneous indurations on the bilateral lower extremities, buttocks, and right forearm. A biopsy of one of the subcutaneous indurations showed non-caseating epithelioid cell granulomas involving the hypodermis and subcutaneous tissues. The patient was diagnosed as having sarcoidosis based on the Japan Society of Sarcoidosis and Other Granulomatous Disorders 2015 criteria. Skin lesions decreased in size and had completely disappeared. Although the mechanism is unknown, there may be a possibility that the activity of sarcoidosis is suppressed by high cortisol concentrations due to Cushing syndrome.
Subject(s)
Adrenal Gland Neoplasms , Cushing Syndrome , Sarcoidosis , Skin Diseases , Adult , Cushing Syndrome/etiology , Female , Granuloma , Humans , Sarcoidosis/pathology , Skin Diseases/etiology , Skin Diseases/pathologySubject(s)
Blister/etiology , Lymphoma, T-Cell/diagnosis , Skin Neoplasms/diagnosis , Aged, 80 and over , CD8 Antigens/metabolism , Diagnosis, Differential , Female , Humans , Lymphoma, T-Cell/complications , Lymphoma, T-Cell/metabolism , Lymphoma, T-Cell/pathology , Pemphigoid, Bullous/diagnosis , Skin Neoplasms/complications , Skin Neoplasms/metabolism , Skin Neoplasms/pathologyABSTRACT
A 34-year-old woman with a past history of inflammatory bowel disease developed a painful elevated edematous swelling with ulcerations on the dorsum of her left foot. Histopathological examination revealed dense infiltration of neutrophils and mononuclear cells in the lower dermis and subcutaneous tissue. Tumor necrosis factor (TNF) was strongly detected in giant cells. To date, only a few cases of pyoderma gangrenosum with granulomatous changes have been reported. Tumor necrosis factor may have played a role in the granulomatous reaction in our case.
