Subject(s)
Prurigo/diagnostic imaging , Skin Neoplasms/diagnostic imaging , Antineoplastic Agents, Immunological/therapeutic use , Fluorodeoxyglucose F18 , Glucose Transporter Type 1/metabolism , Humans , Keratinocytes/metabolism , Lung Neoplasms/drug therapy , Lung Neoplasms/secondary , Male , Melanoma/drug therapy , Melanoma/secondary , Middle Aged , Nivolumab/therapeutic use , Positron Emission Tomography Computed Tomography , Prurigo/metabolism , Prurigo/pathology , Radiopharmaceuticals , Skin Neoplasms/pathologySubject(s)
Melanoma/secondary , Paget Disease, Extramammary/pathology , Scrotum/pathology , Skin Neoplasms/pathology , Administration, Intravenous , Aged , Asian People/ethnology , Docetaxel/administration & dosage , Docetaxel/therapeutic use , Fatal Outcome , Humans , Keratin-7/metabolism , MART-1 Antigen/metabolism , Male , Melanoma/pathology , Neoplasm Metastasis/pathology , Neoplasms, Second Primary/pathology , Paget Disease, Extramammary/metabolism , Paget Disease, Extramammary/ultrastructure , Tubulin Modulators/therapeutic useABSTRACT
Centrifugal lipodystrophy (CLD), characterized by a depressed lesion in the abdominal skin, is a chronic disease occurring more often among younger patients of East Asian descent. We present an extremely unusual case of CLD of the scalp associated with reversible hair loss. The patient demonstrated alopecia in the frontal, temporal and occipital areas of the scalp, which connected to form a ring-shaped area of hair loss. Curiously, the area of hair loss gradually expanded outwards while the central region showed normal hair regrowth. Immunohistochemical analysis demonstrated reduced expression of leptin, an adipokine capable of inducing the anagen phase of the hair cycle, in the adipose tissue, associated with active inflammation. By contrast, recovery of leptin expression was observed at sites of healed inflammatory lesions, suggesting that reversible hair loss might be caused by a change in leptin expression in adipose tissue.
Subject(s)
Alopecia/pathology , Lipodystrophy/pathology , Scalp Dermatoses/pathology , Scalp/pathology , Alopecia/diagnostic imaging , CD4-Positive T-Lymphocytes , CD8-Positive T-Lymphocytes , Female , Humans , Lipodystrophy/diagnostic imaging , Magnetic Resonance Imaging , Scalp/immunology , Scalp Dermatoses/diagnostic imaging , Skin/immunology , Skin/pathology , Young AdultABSTRACT
Epithelioid sarcoma located in the right hip-to-thigh region of a 58-year-old female was studied by light microscopy, immunohistochemistry, and electron microscopy. Light microscopy revealed both light and dark cells among the tumor cells. Round, homogeneous, eosinophilic bodies were noted extracellularly and intracellularly. Extracellular bodies were similar in size to tumor cells and were not stained by PAS or Congo red. In contrast, intercellular bodies were PAS positive and diastase resistant. Tumor cells were positive for vimentin, keratin, and, partially, for epithelial membrane antigen. Ultrastructurally, tumor cells had numerous microfilaments with tonofibril-like arrangement, lipid droplets, and reticulogranular structure in their cytoplasm. The reticulogranular structure was similar to the tonofilaments recognized in degenerative tumor cells. Oval filamentous bodies were recognized in the stroma. They appeared to be very similar to colloid bodies derived from tonofilaments of keratinocytes. It was considered that the filamentous bodies corresponded to extracellular eosinophilic bodies and showed signs of fibrous necrosis of tumor cells. Intracellular eosinophilic bodies were considered to be lipid droplets.
