Subject(s)
AIDS Serodiagnosis , Reagent Kits, Diagnostic , Self Care , HIV Infections/diagnosis , HumansABSTRACT
We measured adult heights (Ht) of 94 healthy GH-sufficient children (peak GH > 10 ng/mL, polyclonal RIA) whose Ht at presentation were more than 2 SD below the mean for chronological age, with normal weight-to-Ht ratios, normal body proportions, and pathologic growth velocity for chronological age. Group 1 (n 36, 6 females) received standardized doses (0.3 mg/kg x week) of GH (mean duration = 41 months), while group 2 (n = 58, 17 females) received no treatment. Our conclusion was that the mean final Ht SD score in the GH-treated group (-1.5) was significantly greater than in the untreated group (-2.1); P < .001. Genetic predisposition to short stature was evident in both groups: the midparental Ht SD score was -1.1 in the treated and -1.0 in the untreated group. Midparental Ht was met or exceeded by 42% of the GH-treated group but only 15% of the untreated group. Final Ht was not significantly different from predicted Ht, except from GH-treated girls, who exceeded their predicted Ht. Although the mean Ht gains (6.8 cm in girls and 3 cm in boys) were modest and variable, GH treatment provided significantly better Ht outcomes for the majority of children with idiopathic growth failure.
Subject(s)
Body Height , Growth Disorders/drug therapy , Human Growth Hormone/therapeutic use , Adolescent , Adult , Child , Female , Growth Disorders/etiology , Humans , Male , PrognosisABSTRACT
Sensitivities of 120 strains of Staphylococcus aureus to methicillin, cetylpyridinium chloride (CPC) and chlorhexidine (CH) were measured by the agar dilution technique. The MICs for CPC and CH were < or = 2 micrograms/ml in 93 and 83% of methicillin-sensitive S. aureus, respectively, and > 2 micrograms/ml in 81 and 83% of methicillin-resistant S. aureus (MRSA), respectively. Overall, the MICs for CPC and CH were 5-10 times greater in the methicillin-resistant than in the methicillin-sensitive strains (p < 0.001). The MICs for CPC and CH also predicted the relative susceptibilities of S. aureus strains to the bactericidal action of these agents in growth and time-kill studies. The possibility that antiseptics and disinfectants contribute to the selection and maintenance of multiply resistant MRSA is considered.
Subject(s)
Anti-Infective Agents, Local/pharmacology , Cetylpyridinium/pharmacology , Chlorhexidine/pharmacology , Methicillin/pharmacology , Staphylococcus aureus/drug effects , Methicillin Resistance , Microbial Sensitivity TestsABSTRACT
The lack of valid and reliable Spanish speech audiometry materials constitutes an important clinical problem. Such tests necessitate the construction of appropriate materials. Analysis of English and Spanish literature on speech audiometry led to the identification of guidelines for new test materials in the Spanish language. Test lists were devised, recorded and used to evaluate 10 normal-hearing native Spanish-speaking subjects. The results obtained led to a final set of recorded lists. Boston College Auditory Test lists may be used successfully with Spanish-speaking patients. The current study should provide the impetus and sufficient guidelines upon which speech stimuli in other languages may be constructed.
