ABSTRACT
The article mentiones issues of preserving and strengthening the reproductive health of women workers, dealed by researchers of the laboratory, established in 1974. It describes the developed concept of the reproductive health problems and scientific research areas, developed documents, including legislative fields, formulates main prospects of the laboratory to meet the requirements of the present moment. Noted the role of the Problem Commission "Scientific basis for the reproductive health of workers", in the work of the Scientific Council on medical and environmental issues of workers' health.
Subject(s)
Environmental Monitoring/methods , Occupational Diseases , Occupational Exposure , Reproductive Health , Workplace , Female , Forms and Records Control , Humans , Maternal Exposure/adverse effects , Maternal Exposure/prevention & control , Occupational Diseases/etiology , Occupational Diseases/physiopathology , Occupational Diseases/prevention & control , Occupational Exposure/adverse effects , Occupational Exposure/prevention & control , Reproductive Health/legislation & jurisprudence , Reproductive Health/statistics & numerical data , Women's Health , Women, Working , Workplace/classification , Workplace/standardsABSTRACT
The article presents results obtained in study of relationship between polymorph variants of CYP1A1 and CYP1A2 genes with reproductive and thyroid diseases risk in female workers of petrochemical industry, when compared with reference group females. Variants TD and DD of CYP1A2 gene appeared to be associated with nodes formation in uterus and breast in female workers and reference group females. Following liability markers are obtained: homozygous in rare allele genotype CC of CYP1A1 gene for reproductive and thyroid diseaes (fibrous cystic mastopathy and nodular goitre), heterozygous genotype AG of CYP1A1 gene in uterine myoma and fibrous cystic mastopathy, homozygous in deleted T genotype of CYP1A2 gene in autoimmune thyroiditis. Occupational hazards and long length of service at hazardous industries increase effects of rare alleles of the genes studied.
Subject(s)
Chemical Industry , Cytochrome P-450 CYP1A1/genetics , Cytochrome P-450 CYP1A2/genetics , Fibrocystic Breast Disease/enzymology , Leiomyoma/enzymology , Occupational Health , Polymorphism, Genetic , Thyroid Diseases/enzymology , Adult , Case-Control Studies , Female , Fibrocystic Breast Disease/epidemiology , Fibrocystic Breast Disease/etiology , Fibrocystic Breast Disease/genetics , Gene Frequency , Genetic Predisposition to Disease , Homozygote , Humans , Leiomyoma/epidemiology , Leiomyoma/etiology , Leiomyoma/genetics , Middle Aged , Occupational Exposure/adverse effects , Occupational Exposure/analysis , Petroleum Pollution/adverse effects , Petroleum Pollution/analysis , Regression Analysis , Russia , Thyroid Diseases/epidemiology , Thyroid Diseases/etiology , Thyroid Diseases/geneticsABSTRACT
Chemicals in the air of workplace within organic synthesis enterprises could induce reproductive disorders in the female workers. Analysis of polymorphous variants of P450 cytochrome gens and antioxidant defence system helped to reveal genetic markers for risk of reproductive disorders in the female examinees.
