[REPARATIVE OSTEOGENESIS AND ANGIOGENESIS UNDER THE CONDITIONS OF TRANSOSSEOUS OSTEOSYNTHESIS AND THE EXPOSURE TO LOW-INTENSITY LASER RADIATION].

The aim of the study was the morphological analysis of the effect of exposure to low-intensity infrared laser radiation on reparative osteogenesis and angiogenesis in bone regenerate formed during the treatment of fracture under the conditions of transosseous osteosynthesis. In the experiment on rats in control (n=16) and experimental (n=16) groups the fracture of the tibia was modeled, and the reposition and fixation of bone fragments with a device for transosseous osteosynthesis was carried out. In animals of the experimental group, the area of the fracture was exposed to pulsed infrared laser radiation of low intensity. In the group of control animals, similar exposure was imitated. The operated bones were studied using radiography, light and electron microscopy, x-ray electron probe microanalysis. It was found that the sessions of laser irradiation reduced the severity of the inflammatory process, stimulated fibrillogenesis and endovascular capillary growth, accelerated the compaction of the newly formed bone, increased the degree of its maturity, with the fracture healing occurring by primary-type mechanism. Laser therapy of the fracture area provides for the formation of bone regenerate and bone fragment unification at an earlier date.

[The effect of implantation of mineralized bone matrix on the regeneration of articular cartilage].

The peculiarities of regeneration of knee articular cartilage were studied experimentally in adult Wistar rats (n = 25) using the methods of optical and electron microscopy, histochemistry and x-ray electron probe microanalysis after modeling marginal perforated defect and implantation of granulated mineralized bone matrix (MBM) into the damaged zone. This biomaterial was demonstrated to have marked chondroinductive properties, to provide prolonged activation of reparative process, accelerated organotypical remodeling and restoration of the damaged articular cartilage. The data obtained indicate the possibility of MBM application in clinical practice for the treatment of injuries and diseases of the articular cartilage.