ABSTRACT
Normal, adenoma and cancer cell nucleoli have been studied by silver impregnation in 13 cancer patients, 48 patients with adenoma (14-tubular, 35-tubulovillous and villous) and 15 controls. It has been shown that the content of silver granules per cell was significantly higher (34.0 +/- 9.7) in cancer cells than in the control (12.3 +/- 3.1). Adenoma cells were heterogeneous. Most villous adenomas, like adenocarcinomas, had high content of Ag granules per cell. The importance of these findings for theoretical and clinical oncology is discussed.
Subject(s)
Carcinoma/ultrastructure , Intestinal Neoplasms/ultrastructure , Intestine, Large/ultrastructure , Nucleolus Organizer Region/ultrastructure , Adenocarcinoma/ultrastructure , Adenoma/ultrastructure , Humans , Intestinal Mucosa/ultrastructure , Staining and Labeling/methodsABSTRACT
The results of post-mortem examination of 532 cases of ovarian malignancies are presented. A certain pattern of metastatic spread was established. Tumors most frequently disseminated into the parietal and visceral peritoneum (93.9%), greater omentum (73.6), lymph nodes (48.2), pleura (31.5) and liver (25.4%). Implantation was shown to be the most common mode of spread. Lymphogenous and hematogenous metastases were of low clinical significance since they did not develop so fast as implantation metastases did which advanced rapidly and determined the clinical course.
Subject(s)
Ovarian Neoplasms/pathology , Carcinoma/pathology , Cystadenocarcinoma/pathology , Dysgerminoma/pathology , Female , Granulosa Cell Tumor/pathology , Humans , Neoplasm Metastasis , Neoplasm Staging , Teratoma/pathology , Thecoma/pathologyABSTRACT
The data on 330 cases of villous and tubular-villous adenoma of the colon were analysed. The results of histological examination of resected material were compared with the evidence provided by clinico-endoscopic examination as well as preoperative bioptic findings. Since none of the above procedures proved to be of diagnostic value in detective invasive growth of villous tumor, it makes the case for total biopsy as the only reliable diagnostic procedure.
Subject(s)
Colonic Neoplasms/diagnosis , Colonic Neoplasms/pathology , HumansSubject(s)
Chromosome Aberrations , Cystadenocarcinoma/drug therapy , Ovarian Neoplasms/drug therapy , Antineoplastic Agents/therapeutic use , Cystadenocarcinoma/genetics , Cystadenocarcinoma/ultrastructure , Female , Humans , Ovarian Neoplasms/genetics , Ovarian Neoplasms/ultrastructure , Ovary/ultrastructureSubject(s)
Cystadenocarcinoma/therapy , DNA, Neoplasm/metabolism , Ovarian Neoplasms/therapy , Preoperative Care , Adult , Aged , Cyclophosphamide/administration & dosage , Cystadenocarcinoma/metabolism , DNA, Neoplasm/analysis , Female , Humans , Middle Aged , Ovarian Neoplasms/metabolism , Thiotepa/administration & dosageABSTRACT
The intraoperative material was examined morphologically in 254 patients, aged from 31 to 71, with serous ovarian cystadenocarcinoma. One hundred patients were not given a preoperative course of chemotherapy, and 154 patients were administered thio-TEPA in various dosage. As a dose of the drug was increased less mitotic activity was noted, which may serve as a quantitative indicator of the chemotherapy efficacy.
Subject(s)
Cystadenoma/drug therapy , Mitosis/drug effects , Ovarian Neoplasms/drug therapy , Adult , Aged , Dose-Response Relationship, Drug , Female , Humans , Lymphatic Metastasis , Middle Aged , Omentum , Peritoneal Neoplasms/secondary , Preoperative Care , Thiotepa/therapeutic useABSTRACT
The authors studied morphologically serous cystic adenocarcinomas of the ovary from 27 patients aged from 30 to 70 years. 100 patients were not given a preoperative course of chemotherapy, and 107 patients received different chemical drugs preoperatively. Changes in the mitotic activity indicate the sensitivity or resistance of the tumor to different chemical drugs.
Subject(s)
Cystadenocarcinoma/pathology , Ovarian Neoplasms/pathology , Adult , Aged , Antineoplastic Agents/administration & dosage , Cystadenocarcinoma/drug therapy , Drug Therapy, Combination , Female , Humans , Middle Aged , Mitosis/drug effects , Ovarian Neoplasms/drug therapy , Preoperative CareSubject(s)
Cystadenocarcinoma/drug therapy , Mitosis/drug effects , Ovarian Neoplasms/drug therapy , Thiotepa/therapeutic use , Adult , Aged , Cystadenocarcinoma/pathology , Dose-Response Relationship, Drug , Drug Evaluation , Female , Humans , Middle Aged , Ovarian Neoplasms/pathology , Preoperative CareABSTRACT
Use of the complex of morphological methods (histological, morphometric, electron microscopy and tissue culture technic) in examining the operation material enabled a more precise and full idea to be formulated of the principal stages of the morphogenesis of serous ovarian cystomas and also allowed the validation of their differentiation between benign, boundary (intermediate) and malignant types.