[Activity of the nucleolar organizers of the cells in epithelial tumors of the human large intestine]. / Aktivnost' iadryshkovykh organizatorov kletok épitelial'nykh opukholei tolstoi kishki cheloveka.

Normal, adenoma and cancer cell nucleoli have been studied by silver impregnation in 13 cancer patients, 48 patients with adenoma (14-tubular, 35-tubulovillous and villous) and 15 controls. It has been shown that the content of silver granules per cell was significantly higher (34.0 +/- 9.7) in cancer cells than in the control (12.3 +/- 3.1). Adenoma cells were heterogeneous. Most villous adenomas, like adenocarcinomas, had high content of Ag granules per cell. The importance of these findings for theoretical and clinical oncology is discussed.

[Patterns in the metastasis of malignant ovarian tumors based on autopsy data]. / O nekotorykh zakonomernostiakh metastazirovaniia zlokachestvennykh opukholei iaichnikov po dannym autopsii.

The results of post-mortem examination of 532 cases of ovarian malignancies are presented. A certain pattern of metastatic spread was established. Tumors most frequently disseminated into the parietal and visceral peritoneum (93.9%), greater omentum (73.6), lymph nodes (48.2), pleura (31.5) and liver (25.4%). Implantation was shown to be the most common mode of spread. Lymphogenous and hematogenous metastases were of low clinical significance since they did not develop so fast as implantation metastases did which advanced rapidly and determined the clinical course.

[Clinico-morphologic comparisons in villous and adenovillous tumors of the colon]. / Kliniko-morfologicheskie sopostavleniia pri vorsinchatykh i zhelezisto-vorsinchatykh opukholiakh tolstoi kishki.

The data on 330 cases of villous and tubular-villous adenoma of the colon were analysed. The results of histological examination of resected material were compared with the evidence provided by clinico-endoscopic examination as well as preoperative bioptic findings. Since none of the above procedures proved to be of diagnostic value in detective invasive growth of villous tumor, it makes the case for total biopsy as the only reliable diagnostic procedure.

[Mitotic activity changes in serous ovarian cystadenocarcinomas under treated with chemotherapy]. / Izmeneniia mitoticheskoi aktivnosti v seroznykh tsistadenokartsinomakh iaichnika pod vliianiem khimioterapii.

The intraoperative material was examined morphologically in 254 patients, aged from 31 to 71, with serous ovarian cystadenocarcinoma. One hundred patients were not given a preoperative course of chemotherapy, and 154 patients were administered thio-TEPA in various dosage. As a dose of the drug was increased less mitotic activity was noted, which may serve as a quantitative indicator of the chemotherapy efficacy.

[Morphological characteristics of serous ovarian adenocarcinomas after chemotherapy]. / Nekotorye morfologicheskie osobennosti seroznykh adenokartsinom iaichnikov posle khimioterapii.

The authors studied morphologically serous cystic adenocarcinomas of the ovary from 27 patients aged from 30 to 70 years. 100 patients were not given a preoperative course of chemotherapy, and 107 patients received different chemical drugs preoperatively. Changes in the mitotic activity indicate the sensitivity or resistance of the tumor to different chemical drugs.

[Morphology and the morphogenesis aspects of ovarian cystomas]. / Morfologiia i nekotorye aspekty morfogeneza kistom iaichnikov.

Use of the complex of morphological methods (histological, morphometric, electron microscopy and tissue culture technic) in examining the operation material enabled a more precise and full idea to be formulated of the principal stages of the morphogenesis of serous ovarian cystomas and also allowed the validation of their differentiation between benign, boundary (intermediate) and malignant types.