ABSTRACT
[This corrects the article DOI: 10.1371/journal.pone.0243966.].
ABSTRACT
In this paper, we provide a retrospective cohort study with patients that have been hospitalized for general or intensive care unit admission due to COVID-19, between March 3 and July 29, 2020, in the state of Bahia, Brazil. We aim to correlate those patients' demographics, symptoms and comorbidities, with the risk of mortality from COVID-19, length of hospital stay, and time from diagnosis to definitive outcome. On the basis of a dataset provided by the Health Secretary of the State of Bahia, we selected 3,896 hospitalized patients from a total of 154,868 COVID-19 patients that included non-hospitalized patients and patients with invalid registration in the dataset. Then, we statistically analyzed whether there was a significant correlation between the patient record data and the COVID-19 pandemic, and our main findings reinforced by the use of a multivariable logistic regression were that older age (Odds Ratio [OR] = 1.03, 95% Confidence Interval [CI] = 1.03-1.04, p-value (p) <0.001), an initial symptom of shortness of breath (OR = 1.88, 95% CI = 1.60-2.20, p < 0.001), and the presence of comorbidities, mainly chronic kidney disease (OR = 2.41, 95% CI = 1.67-3.48, p < 0.001) are related to an increased risk of mortality from COVID-19. On the other hand, sore throat (OR = 0.74, 95% CI = 0.58-0.95, p = 0.02) and length of hospital stay (OR = 0.96, 95% CI = 0.58-0.95, p < 0.001) are more related to a reduced risk of mortality from COVID-19. Moreover, a multivariable linear regression conducted with statistically significant variables (p < 0.05) showed that age (OR = 0.97, 95% CI = 0.95-0.98, p < 0.001) and time from diagnosis to definitive outcome (OR = 1.67, 95% CI = 1.64-1.71, p < 0.001) are associated with the length of hospital stay.
Subject(s)
COVID-19/epidemiology , Coronavirus Infections/epidemiology , Pandemics , Pneumonia, Viral/epidemiology , Adult , Aged , Brazil/epidemiology , COVID-19/complications , COVID-19/therapy , COVID-19/virology , Comorbidity , Coronavirus Infections/complications , Coronavirus Infections/therapy , Coronavirus Infections/virology , Female , Hospitalization , Humans , Intensive Care Units , Male , Middle Aged , Pneumonia, Viral/complications , Pneumonia, Viral/therapy , Pneumonia, Viral/virology , Respiration, Artificial/methods , Risk Factors , SARS-CoV-2/pathogenicityABSTRACT
About 14% of all substance abuse urine tests are positive for 1.2 substances. Cannabinoid and cocaine metabolites are most frequently the cause of positivity. Individuals in probation or parole programs have the highest numbers of positive urine substance abuse tests. Our data suggest that a consistency of positivity exists for substance abuse urine tests and that this positivity, once developed by testing laboratories, can be used for purposes of contractual relations and cost predictions. Valuable educational information that may assist the population serviced by the laboratory in regard to substance abuse can also be obtained.
Subject(s)
Substance Abuse Detection , Urine/analysis , HumansABSTRACT
Cells resembling Sternberg-Reed cells were observed in a pleural effusion that was caused by pulmonary embolus with infarction. Although Hodgkin's disease was suggested on the basis of abnormal pleural fluid cytological preparations, the subsequent evaluation and clinical course did not support that diagnosis. We conclude that first, the cytological diagnosis of Hodgkin's disease should only be made when Sternberg-Reed-like cells are seen in association with a compatible clinical and cytological picture, and second, the cytological diagnosis of Hodgkin's disease or other malignancy should be made with caution in cases in which pulmonary infarction is present.
Subject(s)
Hodgkin Disease/diagnosis , Pleural Effusion , Pulmonary Embolism/diagnosis , Adult , Cytodiagnosis , Diagnosis, Differential , Female , Hodgkin Disease/pathology , Humans , Pleura/diagnostic imaging , Pleural Effusion/cytology , Pleural Effusion/etiology , Pneumomediastinum, Diagnostic , Pulmonary Embolism/pathology , Radionuclide ImagingABSTRACT
A case of multiple giant cell tumors is reported. Neither of the lesions was malignant. The clinical, pathologic, and radiographic features of giant cell tumors are discussed.
Subject(s)
Bone Neoplasms , Giant Cell Tumors , Neoplasms, Multiple Primary , Adult , Bone Neoplasms/diagnostic imaging , Bone Neoplasms/pathology , Giant Cell Tumors/diagnostic imaging , Giant Cell Tumors/pathology , Humans , Male , Neoplasms, Multiple Primary/diagnostic imaging , Neoplasms, Multiple Primary/pathology , RadiographyABSTRACT
A comparison of standard Wright's stained lupus erythematosus preparations and an acridine orange fluorochromatic method was conducted using 354 consecutive lupus erythematosus preparations involving 264 patients. The results of this comparison and a discussion of the fluorochromatic procedure are presented.
