[Features of mast cell status and blood coagulation during long-term administration of noradrenaline in mountain dogs]. / Osobennosti sostoianiia tuchnykh kletok i gemokoaguliatsii pri dlitel'nom vvedenii noradrenalina u gornykh sobak.

The total number of mast cells and their forms is increased, degranulation is weakly marked in dogs permanent of medium altitude (1650 m) in comparison with low altitude dogs (760 m) after the long-term NA injections addition with reaction similarities some differences were observed. The total number of mast cells is decreased less considerably, the number of average forms of maturity and to some extent the number of the third power degranulation are increased in altitude dogs. The decrease of the high altitude adaptive heparin level is observed, the activity of fibrinolytic system is marked facilitating the prevention of microcirculatory disturbances. Thus, mast cells and hemocoagulation systems of altitude are more resistant to the long-term noradrenaline loadings.

[Mast cell and blood coagulation functions during prolonged noradrenaline administration]. / Sostoianie tuchnykh kletok i gemokoaguliatsii pri dlitel'nom vvedenii noradrenalina.

During the long term noradrenaline injection (0.56 microgram/kg/min-2 hours during six days) the number of connective tissue mast cells decreases in dogs. Mature cells disappears and the percentage of young forms increases. Marked degranulation develops. 5-10 cell groups and chains are formed. The increase of free heparin level and the activation of anticoagulant unit hemostasis correspond to these changes. It is due to mast cells discharge of biologically active heparin which is an unspecific adaptogen.

[Learning of animals during adaptation to altitude and its relations with serotonin metabolism in the brain]. / Obuchenie zhivotnykh v usloviiakh adaptatsii k vysokogor'iu i ego sviaz's obmenom serotonina mozga.

The influence of high altitude (3 200 m) on learning was studied on 104 non-linear male rats weighing 120 to 140 g, along with biochemical analysis of serotonin content (5-HT) and noradrenaline (NA) in brain structures. A drastic deterioration in the animals' learning has been established in conditions of high altitude, both with alimentary and pain reinforcement attended with a considerable suppression of the 5-HT and NA brain systems activity. Systematic administration of 5-HTP resulting in an enhanced serotonin level in the cortex and the caudal part of the brainstem, improved the learning process, regardless of the emotional sign of the reinforcing stimulus. The prospect, is being substantiated, of evolving methods preventing pathological implications of external influences of high altitudes on the organism by means of pharmacological actions on monoamines' metabolism.

[Decrease in the radiation effect in the lymphoid organs of animals adapting to altitude]. / Snizhenie radiatsionnogo éffekta v limfoidnykh organakh zhivotnykh pri adaptatsii k vysokogor'iu.

Adaptation to altitude hypoxia exerts a positive effect on the cell density of lymph organs of gamma-irradiated animals. It also reduces radiation degradation of DNA, its availability to DNase in the nuclear chromatin and disorders in the activity of DNA polymerases. The role of inhibition of radiation-induced degradation of chromatin DNA in the protective effect of altitude adaptation on the cell density of lymph organs is discussed.

[Circadian rhythms in connective tissue]. / O tsirkadnykh ritmakh v soedinitel'noi tkani

A study of circadian rhythms in the connective tissue showed cell elements (particularly histiocytes) to be characterized by circadian rhythms of the metabolic processes. This is expressed in a distinct diurnal activity of the succinic dehydrogenase (SDH) and lactic dehydrogenase (LDH). In the processes of adaptation to the high altitude hypoxia the activity of SDH and LDH was higher than in control, but dynamics of the changes of their activity repeated the changes in control group. It is concluded that circadian rhythms of the metabolic processes in the connective tissue were sufficiently stable: no visible changes were observed during adaptation to high altitudes.