ABSTRACT
Pancreatic endocrine function was investigated in 43 patients with nonspecific ulcerative colitis by studying the blood concentrations of insulin, C-peptide and glucagon using a radioimmunoassay. In such patients the level of C-peptide was on a decrease, that of glucagon--on an increase. The level of insulin in nonspecific ulcerative colitis showed a tendency to increase. These alterations were closely connected with pancreatic excretory function. The most profound changes were noted in patients with markedly lowered pancreatic excretory function.
Subject(s)
Colitis, Ulcerative/physiopathology , Pancreas/metabolism , Adolescent , Adult , Aged , Blood Glucose/analysis , C-Peptide/blood , Colitis, Ulcerative/blood , Female , Glucagon/blood , Humans , Insulin/blood , Male , Middle AgedABSTRACT
The functional condition of the biliary system and the changes in the biochemical composition of the bile were studied in 62 patients with ulcerative colitis. In most patients changes in the contractile and motor function of the gallbladder were observed. The rate of occurrence and the extent of these changes are associated with the severity and duration of the main disease. Disturbances in the biochemical composition of the bile were observed in all the groups of patients, but the most pronounced changes were found in severe cases of ulcerative colitis. The choleretic Flamin was introduced into the complex therapy of the patients with ulcerative colitis to make the correction of these disturbances possible. The examination program for the patients with ulcerative colitis is supposed to include the laboratory and roentgenologic investigations which characterize the condition of the biliary system.
