[Fungal myocarditis in deep visceral candidiasis]. / Gribkovyi miokardit pri glubokom vistseral'nom kandidoze.

Morphological and functional changes of the myocardium were studied in 40 patients with candidiasis and attempt to establish morphological criteria of fungal myocarditis was undertaken. Retrospective analysis of autopsy material showed that myocardial involvement in candidiasis was possible and was not as rare as it had been accepted. Clinical symptomatology was not always similar to that of classical infectious-allergic myocarditis. However immunological parameters were characteristic of inflammatory process. Complex echocardiographic study gave important information for assessment of the state of the myocardium.

[Pathomorphology of adrenergic and cholinergic structures of sympathetic nerve ganglia in experimental burn injuries]. / Patomorfologiia adren- i kholinergicheskikh struktur simpaticheskikh nervnykh gangliev pri éksperimental'noi ozhogovoi travme.

Changes in adreno- and cholinergic structures of sympathetic nerve ganglia (superior cervical, stellate, and splanchnic ganglia of the solar plexus) were studied in 15 male white rats aged 5-7 months, b. m. 200-250 g, 3, 7, and 11 days after burn injury (Stages IIIA, IIIB, involving 20-25% of body surface) and in 5 reference animals. The sections were treated in 2% glyoxylic acid solution and by the Karnovsky-Roots technique. Reduced catecholamine concentrations were revealed in sympathetic nerve ganglia neurons in the early periods after burn injury; the mediator reserves are recovered to a certain measure in later periods after thermal injury. The detected shifts in the sympathetic nerve ganglia neurons correlate with the detected shifts in the cardiovascular system.

[Ultrastructural changes in the sympathetic ganglia in experimental burn trauma]. / Ul'trastrukturnye izmeneniia vegetativnykh nervnykh gangliev pri éksperimental'noi ozhogovoi travme.

Ultrastructural changes of neurones of sympathetic vegetative nervous ganglia were studied in 15 white male rats at an age of 5-7 months. In the dynamic of postmortem changes disorders typical of hypoxic conditions of the chest predominated.

[Histofluorescence and histochemical analysis of adrenergic and cholinergic innervation of the lungs in burns]. / Gistofliuorestsentnyi, gistokhimicheskii analiz adren-i kholinergicheskoi innervatsii legkikh pri ozhogovoi bolezni.

Neurohistochemical methods were applied to study adrenergic and cholinergic nervous structures of pulmonary tissue in 30 patients aged 14-82 who had died of burn disease at various stages of its progress (shock, toxemia, septic toxemia). Autopsies performed within 4 hours after the patients' death evidenced mediators depletion in perivascular and peribronchial plexuses as well as intensive luminescence of nervous fibers considered as compensatory adaptation. There was cholinesterase hypoactivity in cholinergic plexuses. It is established that the failure of adaptive-trophic sympathetic regulation of pulmonary tissues including relevant vessels and bronchi results in diminution of pulmonary compensatory and adaptive potential. This should be allowed for in the treatment of burn disease complications.

[Ultrastructure of nodose ganglia of the vagus nerve in burns]. / Ul'trastruktura uzlovatykh gangliev bluzhdaiushchikh nervov pri ozhogovoi bolezni.

Ultrastructural changes of neurons of vagus nodal ganglia on section material of 30 dead persons in different periods of burn disease aged from 14 to 75 have been studied. Examination of the state of the nodal ganglia in different periods of burn disease showed ultrastructural changes in neurons, glial cells, blood capillary endotheliocytes, mitochondria, endoplasmatic net nuclei and cell membranes. The most marked destructive changes were seen in patients who died in late term of burn disease.

[The ultrastructural changes in the central and peripheral nervous system in burns]. / Ul'trastrukturnye izmeneniia v tsentral'noi i perifericheskoi nervnoi sisteme pri ozhogovoi bolezni.

Ultrastructural changes of the brain neurons and vegetative nerve ganglions (superior cervical ganglions, ganglion stellatum, ganglions of vagus nerve) were studied on the autopsy material of 30 patients dying at various periods of burn disease at the age of from 19 to 75 years (burn disease III-IV degree, 35-50% of the body surface) and on the experimental material as well. Ultrastructural changes of neurons, their processes, synapsis apparatus, glial cells, mitochondria, endoplasmatic network nuclei and cell membranes are described. The degree of the destructive changes in central nervous system and vegetative nervous ganglions depends upon the period of burn disease and the size of surface burned.

[The pathomorphology of the superior cervical sympathetic ganglia in burns]. / Patomorfologiia verkhnikh sheinykh simpaticheskikh gangliev pri ozhogovoi bolezni.

Structural changes of upper cervical sympathetic ganglions of 75 patients who died in different stages of burn disease at the age of 19-85, were studied by neurohistological and neurohistochemical methods. It was determined that neurones change at earlier stages of burn disease begins with their reactivity increase. Later hypertrophy, atrophy and decay of neurones body take place. Sharp cateholamine exhaustion in the structures of upper cervical sympathetic ganglions is also determined during the first days of burn trauma (burn shock stage). Some restoring of mediator stock takes place in subsequent periods of burn disease.

[Pathomorphology of stellate ganglia in thermal injuries of the body]. / Patomorfologiia zvezdchatykh gangliev pri termicheskikh porazheniiakh organizma.

Structural changes of stellate-ganglia in 80 patients aged from 20 to 80 dead in different stages of burn disease (shock, toxemia, septico-toxemia and burn exhaustion) were studied with neurohistological and neurohistochemical methods. It was determined that the increasing of neuron's reactivity was the sign of its changes at the early stages of burn disease. Later hypertrophy, atrophy and neuron's body destruction took place. At the period of burn shock excessively bright luminescence sympathetic neurons prevailed, at the period of toxemia its number decreased. At the period of toxemia and septico-toxemia for the first time it was determined the increase of lipofuscin insertion in adrenergic neurons as well as the increase of the activity not only at the shock period but also at the next periods of burn disease.

[Neurohistochemical study of autonomic nerve ganglia and lungs in burns]. / Neirogistokhimicheskoe izuchenie vegetativnykh nervnykh gangliev i legkikh pri ozhogovoi bolezni.

Adreno-cholinergic nerve structures of vegetative nerve ganglia and lungs in 20 departed in different periods of burn disease aged from 19 to 85 have been studied with neurohistological methods. Definite dynamics of mentioned structure changes have been shown. It was stated that in different stages of burn disease adreno-cholinergic nerve structures of vegetative nerve ganglia and lung tissues changed greatly and afferent part suffered more in comparison with efferent one. Adrenergic fluorescence was considerably weaker in elderly and senile patients in comparison with younger ones. Luminescence deterioration was more noticeable in neuron cytoplasm. In young aged such nerve structures were more reactive and remarkable with more compensating abilities.

[Pathomorphologic changes of the solar plexus ganglia in burn disease]. / Patomorfologicheskie izmeneniia gangliev solnechnogo spleteniia pri ozhogovoi bolezni.

Solar ganglia taken from 64 subjects who died in different periods of burn disease: (shock, toxemia septico toxemia, and burn exhaustion) were pathomorphologically examined. The specific time course of changes in solar ganglia was established in various periods of the disease. Dystrophic changes, necrosis of individual neuron groups, and varices of myelinated fibers were detected during burn shock, hypertrophic neurons with thick processes interwoven in between as "felt" predominanted in toxemia whereas in septicotoxemia and burn exhaustion, necrotic changes in neurons and degeneration of nerve fibrous bundle.

[Pathomorphology of the nodose ganglia of the vagus nerves in burns]. / Patomorfologiia uzlovatykh gangliev bluzhdaiushchikh nervov pri ozhogovoi bolezni.

Pathomorphology of ganglion nodosum was studied by means of neurohistological methods in 65 dead patients during different periods of burn disease and demonstrated a definite dynamic of structural modifications. In period of burn shock there were discovered dystrophic changes and necrosis of neuron separate groups, varicose thickness of a myelin sheath, in period of toxemia hypertrophied neurons with thick axons predominated, in period of septic toxemia and burn exhaustion predominated atrophic changes, necrotic neurons and grain-blockage disintegration of nervous fibres.

[Age and changes in the adrenergic nerve supply of the lungs and various clinical aspects of the problem]. / Vozrastnye izmeneniia adrenergicheskogo nervnogo apparata legkikh i nekotorye klinicheskie aspekty problemy.

By means of classical neurohistological techniques and methods for revealing cholinergic and adrenergic neural plexuses, the development of pulmonary innervation has been studied in embryos and fetuses of the human being and rabbit. The mediatory stage in development of the pulmonary innervation begins on the 3d month of the human intrauterine development. The next important stages are the middle of the prenatal development and the 7th month of pregnancy, when an essential complication of the lung innervation takes place. By birth the neural apparatus of the human and rabbit lung is mainly formed, nevertheless, in 15% of newborns its underdevelopment occurs. This may be a predisposing factor for development of certain pathological processes, in particular, pneumosclerosis, and is demonstration of defective formation of the pulmonary parenchyma in some newborns. The principle on coincidence of the beginning of the mediatory stage in the development of the neural plexuses and the beginning of the fetal stage are supposed by the analysis of the pulmonary innervation development in the rabbit.