[Elimination of glycosaminoglycans in duodenal peptic ulcer and problems of its pathogenesis]. / Vydelenie glikozaminoglikanov pri iazvennoi bolezni dvenadtsatiperstnoi kishki i nekotorye voprosy ee patogeneza.

Changes in the excretion and composition of proteoglycans specific for duodenal ulcer were studied in 50 patients with duodenal ulcer, 30 patients with gastric ulcer, 30 patients with chronic endogenous gastroduodenitis and in 35 healthy persons. In all the examinees proteoglycans were isolated from daily urine, their carbohydrate components--glycosaminoglycans (GAG)--were separated and divided into fractions (keratan sulfate, hyaluronic acid, heparan sulfate, chondroitin sulfate-4, chondroitin sulfate-6, dermatan sulfate, and heparin) by column chromatography on unmodified cellulose. It has been established that only peptic ulcer is characterized by disorders in GAG excretion differing in the period of exacerbation and remission. Changes in the composition of proteoglycans excreted with urine resulted probably from a deficiency of chondroitin sulfate-6 in patients with chronic duodenal ulcer. The deficiency was more marked during exacerbation but did not disappear in the period of remission of duodenal ulcer either.

[Excretion of various glycosaminoglycans in patients with chronic duodenal ulcer]. / Vydelenie razlichnykh glikozaminoglikanov u bol'nykh khronicheskoi duodenal'noi iazvoi.

Excretion of individual glycosaminoglycans (GAG's) with urine was studied in patients with chronic duodenal ulcer. 31 patient with acute manifestations of the duodenal ulcer, 24 patients within the period of remission as well as 29 practically healthy persons were studied. Column chromatography on cellulose was used for separation of a mixture containing keratan sulfate, hyaluronic acid, heparan sulfate, chondroitin-4 and -6-sulfates, dermatan sulfate and heparin. During the acute period of duodenal ulcer daily excretion of all the individual GAG's with urine was decreased (especially distinct for the fraction of chondroitin-6-sulfate) as compared with excretion of these carbohydrates in healthy persons. The level of GAG excretion was increased distinctly, exceeding the values found in healthy persons, during the remission. Excretion of chondroitin-6-sulfate and keratan sulfate was markedly increased in these cases.