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[Analysis of chromosome translocations involving MML by hybridization with an oligonucleotide microarray]. / Analiz khromosomnykh translokatsii s uchastiem gena MLL metodom gibridizatsii s oligonukleotidnym mikrochipami.

Mitiaeva, O N; Nasedkina, T V; Zharinov, V S; Isaeva, E A; Turygin, A Iu; Chupeeva, V V; Kreindlin, E Ia; Mirzabekov, A D.

Mol Biol (Mosk) ; 38(3): 449-56, 2004.

Article in Russian | MEDLINE | ID: mdl-15285614

ABSTRACT

Identification of chromosome rearrangements is of importance for exact diagnosis, risk assessment, and therapy in blood malignancies. A new method was proposed for rapid and accurate identification of leukemia forms caused by chromosome rearrangements involving MLL (11q23). The method combines reverse transcription-multiplex PCR and hybridization with an oligonucleotide microarray. The microarray was designed to detect the five most common MLL rearrangements: t(4;11) MLL/AF4, t(9;11) MLL/AF9, t(11;19) MLL/ELL, t(11;19) MLL/ENL, and dup(11) MLL/MLL. With clinical specimens, the method was shown to efficiently identify the chromosome translocations in leukemia patients.

Subject(s)

DNA-Binding Proteins/genetics , Nucleic Acid Hybridization , Oligonucleotide Array Sequence Analysis , Proto-Oncogenes/genetics , Transcription Factors/genetics , Translocation, Genetic , Base Sequence , Cell Line , Chromosomes, Human, Pair 11 , Chromosomes, Human, Pair 4 , DNA Primers , Histone-Lysine N-Methyltransferase , Humans , Myeloid-Lymphoid Leukemia Protein

[Simple method of preparation of a semifluid coating medium with methylcellulose for the determination of the plaque-forming abilities of viruses]. / Prostoi sposob prigotovleniia poluzhidkoi sredy pokrytiia s metiltselliulozoi dlia opredeleniia bliashkoobrazuiushchei sposobnosti virusov

Zuev, V A; Mirchink, E P; Peters, V V; Isaeva, E A.

Lab Delo ; (1): 56-7, 1975.

Article in Russian | MEDLINE | ID: mdl-45981

Subject(s)

Methylcellulose , Viral Plaque Assay/methods , Viruses/isolation & purification , Influenza A virus/isolation & purification , Vaccinia virus/isolation & purification

[Reactions of the organism to cooling with different contents of microelements in the diet]. / Reaktsiia organizma na okhlazhdenie pri razlichnom soderzhanii mikroélementov v ratsione.

Kolomiitseva, M G; Voznesenskaia, F M; Isaeva, E A.

Gig Sanit ; 35(9): 32-6, 1970 Sep.

Article in Russian | MEDLINE | ID: mdl-5501791

Subject(s)

Diet , Hypothermia, Induced , Trace Elements , Animals , Blood Bactericidal Activity , Male , Muramidase/blood , Phagocytosis , Rats

[Immunobiologic reactivity of the animal organism with regard to various concentrations of copper in its rations]. / Immunobiologicheskaia reaktivnost'zhivotnogo organizma v sviazi s razlichnym soderzhaniem medi v ratsionakh.

Kolomiitseva, M G; Voznesenskaia, F M; Isaeva, E A.

Zh Mikrobiol Epidemiol Immunobiol ; 46(8): 99-104, 1969 Aug.

Article in Russian | MEDLINE | ID: mdl-5362270

Subject(s)

Animal Nutritional Physiological Phenomena , Blood Bactericidal Activity/drug effects , Copper , Immunity, Active/drug effects , Phagocytosis/drug effects , Animals , Diet , Leukocytes/drug effects , Muramidase/analysis , Rats

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