[Sex hormones in dyslipoproteinemias and disorders of arterial blood pressure in boys 11-12 years of age]. / Polovye gormony pri dislipoproteidemiiakh i otkloneniiakh arterial'nogo davleniia u mal'chikov 11-12 let.

A survey of boys with hypercholesterolemia, hypertriglyceridemia, hypo-alpha-cholesterolemia, a combination of hypo-alpha-cholesterolemia and hypertriglyceridemia, and hyperalphacholesterolemia, and control subjects from two Moscow districts demonstrated significantly elevated plasma testosterone and estradiol values in boys with hypo-alphacholesterolemia. Increased estradiol was also found in boys with hypercholesterolemia and hyperalphacholesterolemia. An inverse relationship between plasma testosterone level and high density lipoprotein (HDLP) cholesterol, and a direct relationship between the estradiol/testosterone ratio and HDLP cholesterol were established. Individuals with high testosterone and estradiol levels had elevated systolic arterial BP, and those with high systolic arterial BP showed increased testosterone and estradiol levels. It is suggested that reduced high density lipoprotein cholesterol and elevated systolic arterial BP in boys with increased testosterone levels may be regarded as early signs of developing hypo-alphacholesterolemia in combination with arterial hypertension.

[Changes in the basic risk factors for ischemic heart disease in Moscow boys over the period of a year: natural dynamics and the effects of prophylactic action]. / Izmeneniia za 1 god osnovnykh faktorov riska ishemicheskoi bolezni serdtsa u mal'chikov-moskvichei: estestvennaia dinamika i éffekty profilakticheskogo vozdeistviia.

The rise in mean blood plasma levels of total cholesterol, LDL cholesterol and VLDL cholesterol over a one-year period has been observed in Moscow boys (aged from 12 to 13 years). Mean systolic blood pressure (SBP) in this period remained unchanged. In the district where preventive therapy was performed we have observed the decrease in mean levels of total cholesterol, LDL cholesterol, VLDL cholesterol and SBP over a one-year period in boys of the same age group. Age-dependent increment in Ketle index was significantly lower in this district. This indicates that preventive measures have a positive effect on the formation and development of CHD risk factors in children.

[Epidemiologic and preventive studies of the precursors of atherosclerosis in children and adults]. / Epidemiologicheskie i profilakticheskie issledovaniia predvestnikov ateroskleroza u detei i podrostkov.

A total of 1920 schoolchildren of both sexes were examined at 12 to 13 years of age, with a follow-up of 242 children showing elevated BP and a random normotensive sample of 230. A set of features was identified that showed the greatest predictive value with respect to mean BP at five years' follow-up: baseline BP, the Katle index, the magnitude of the S wave and heart rate. A study of possible approaches to the prevention of atherosclerotic precursors in eleven-year-olds has been launched, with the action on certain risk factors, such as limited physical activity, elevated BP, smoking, excessive body weight lipid disorders (in boys only).