1.
Transplant Proc
; 33(6): 2962-3, 2001 Sep.
Article
in English
| MEDLINE
| ID: mdl-11543812
Subject(s)
Immunosuppressive Agents/pharmacology , Liver Circulation/drug effects , Liver/physiology , Tacrolimus/pharmacology , Animals , Aspartate Aminotransferases/blood , Homeostasis/drug effects , In Vitro Techniques , Liver/drug effects , Liver/immunology , Male , Perfusion , Rats , Rats, Wistar
2.
Harefuah
; 138(10): 817-9, 911, 2000 May 15.
Article
in Hebrew
| MEDLINE
| ID: mdl-10883243
ABSTRACT
Deterioration of hepatic function following liver transplantation is a known complication, sometimes attributed to the use of cyclosporin A. Reaction to tacrolimus (Prograf), a relatively new and effective immunosuppressant drug, is thought to result in a much lower grade of organ dysfunction, especially in the transplanted liver. Using the ex-vivo rat model of isolated perfused liver, we evaluated hepatocellular damage and oxygen extraction when tacrolimus was administered following liver hypoperfusion. Tacrolimus did not worsen hepatic dysfunction caused by the hypoperfusion. Therefore using tacrolimus in the perioperative period might be safer than cyclosporin A, which tends to worsen hepatic damage in the presence of hypoperfusion.