Subject(s)
Radiculopathy/diagnosis , Radiculopathy/etiology , Turner Syndrome/complications , Turner Syndrome/diagnosis , Vertebral Artery Dissection/complications , Vertebral Artery Dissection/diagnosis , Cervical Vertebrae/diagnostic imaging , Diagnosis, Differential , Female , Humans , Middle Aged , Radiculopathy/therapy , Tomography, X-Ray Computed/methods , Turner Syndrome/therapy , Vertebral Artery Dissection/therapyABSTRACT
Cerebrotendinous xanthomathosis (CTX) is a rare autosomal-recessively transmitted disease of the lipid storage system with an array of general and neurological symptoms, based on the pathological storage of cholestanol and cholesterol. The histologic manifestations are foamy cell granulomata and cholesterol crystals within various tissues, associated with a loss of both nerve cells and demyelination inside the CNS. We present a case of CTX with clinical progression as well as the pathomorphologic autopsy findings. The CNS affection in our case will be demonstrated and the pathogenesis be discussed. Medical treatment of CTX is possible but with variable success. In the case shown, the patient profited only marginally from a long-term application of chenodeoxycholic acid.
Subject(s)
Xanthomatosis, Cerebrotendinous/pathology , Adult , Chenodeoxycholic Acid/therapeutic use , Gastrointestinal Agents/therapeutic use , Humans , Male , Xanthomatosis, Cerebrotendinous/complications , Xanthomatosis, Cerebrotendinous/drug therapyABSTRACT
Despite the introduction of local thrombolytic therapy, there is still a very high mortality rate in basilar thrombosis. We report three cases of successful intra-arterial thrombolysis of acute basilar artery occlusion and consecutive interventional endovascular therapy. In all cases, the acute thrombosis of the basilar artery probably developed from preexisting atherosclerotic stenoses. The clinical outcomes were excellent. We discuss early consecutive stenting as a possible therapeutic option in cases of residual stenosis after successful intra-arterial lysis of basilar artery occlusion.