1.
J Clin Pharm Ther
; 34(4): 485-7, 2009 Aug.
Article
in English
| MEDLINE
| ID: mdl-19583682
ABSTRACT
Serotonin syndrome is a potentially life-threatening disorder of excessive serotoninergic activity often due to drug interactions. We report a case of serotonin syndrome induced by pharmacokinetic and pharmacodynamic interactions between three different selective serotonin-reuptake inhibitors (SSRI) and possibly ciprofloxacin. Extreme caution is necessary in patients treated with serotonin-reuptake inhibitors who need to be switched to another antidepressant or when they require the addition of concomitant drugs, especially serotoninergic drugs and isoenzimes of cytochrome P450 inhibitors.
Subject(s)
Ciprofloxacin/adverse effects , Selective Serotonin Reuptake Inhibitors/adverse effects , Serotonin Syndrome/chemically induced , Aged , Anti-Infective Agents/adverse effects , Anti-Infective Agents/pharmacology , Antidepressive Agents/adverse effects , Antidepressive Agents/pharmacology , Ciprofloxacin/pharmacology , Drug Interactions , Humans , Male , Selective Serotonin Reuptake Inhibitors/pharmacokinetics
2.
Aten Primaria
; 8(1): 1, 1991 Jan.
Article
in Spanish
| MEDLINE
| ID: mdl-1912205