1.
Chem Pharm Bull (Tokyo)
; 57(10): 1103-6, 2009 Oct.
Article
in English
| MEDLINE
| ID: mdl-19801866
ABSTRACT
First syntheses of sesquiterpene quinones (-)-tauranin and (-)-BE-40644 which exhibited strong cytotoxicity against several cancer cell lines, were achieved from (8aS)-albicanol obtained by enzymatic optical resolution. By comparison of the sign of specific rotation between synthetic (12bS)-BE-40644 and natural (-)-BE-40644, the absolute configurations of natural (-)-BE-40644 were determined to be 4aS, 6aS, 12aR, 12bS.