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Org Lett ; 10(23): 5465-8, 2008 Dec 04.
Article in English | MEDLINE | ID: mdl-18975955

ABSTRACT

The novel alkaloids cylindradines A and B were isolated from Axinella cylindratus, and their structures were elucidated by spectroscopic analyses. Stereochemistries of these compounds were determined by X-ray analysis. Cylindradines showed moderate inhibitory activity against the murine leukemia cell line P388.


Subject(s)
Alkaloids/chemistry , Alkaloids/pharmacology , Axinella/chemistry , Pyrroles/chemistry , Alkaloids/isolation & purification , Animals , Cell Line, Tumor , Chromatography, High Pressure Liquid , Inhibitory Concentration 50 , Magnetic Resonance Spectroscopy , Mice , Pyrroles/isolation & purification , Pyrroles/pharmacology
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