1.
Agric Biol Chem
; 54(11): 2875-81, 1990 Nov.
Article
in English
| MEDLINE
| ID: mdl-1369312
ABSTRACT
Streptomyces griseus and bacteriophage B were used for an assay system detecting anti-bacteriophage antibiotics. Streptomyces sp. RK-1441 was found to produce antibacteriophage antibiotics, RK-1441A and B, which are pyrrolo[1,4]benzodiazepine group antibiotics related to neothramycin. Both RK-1441A and B had antibacteriophage activity. The former showed antimicrobial activity on a hypersensitive strain of E. coli for antitumor antibiotics, but the later did not show the activity. Restriction enzyme assay suggested that RK-1441A formed adducts with guanine residues in DNA strands. RK-1441B was not active in vitro, but it might be converted to the active form in host organisms.
Subject(s)
Anti-Bacterial Agents/pharmacology , Streptomyces/metabolism , Anti-Bacterial Agents/biosynthesis , Anti-Bacterial Agents/metabolism , Antibiotics, Antineoplastic/pharmacology , Bacteriophages/drug effects , Benzodiazepinones/metabolism , Benzodiazepinones/pharmacology , Cell Survival , DNA Restriction Enzymes/metabolism , DNA, Viral/analysis , DNA, Viral/metabolism , Fermentation , Humans , Leukemia, Experimental , Microbial Sensitivity Tests , Streptomyces/classification , Tumor Cells, Cultured/drug effects
2.
Kango Kyoiku
; 19(11): 661-2, 1978 Nov.
Article
in Japanese
| MEDLINE
| ID: mdl-251688
3.
Kango
; 28(11): 130-40, 1976 Nov.
Article
in Japanese
| MEDLINE
| ID: mdl-1050463
Subject(s)
Amyotrophic Lateral Sclerosis , Community Health Nursing , Nursing Records , Humans , Male
4.
Kangogaku Zasshi
; 35(10): 84-7, 1971 Oct.
Article
in Japanese
| MEDLINE
| ID: mdl-5002074
5.
Kangogaku Zasshi
; 35(4): 11-4, 1971 Apr.
Article
in Japanese
| MEDLINE
| ID: mdl-4995177
6.
Kangogaku Zasshi
; 35(4): 15-8, 1971 Apr.
Article
in Japanese
| MEDLINE
| ID: mdl-4995178