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Cancer Lett ; 291(2): 225-9, 2010 May 28.
Article in English | MEDLINE | ID: mdl-19900759

ABSTRACT

Extracellular adenosine-induced apoptosis of HepG2 cells, a human hepatoma cell line, in a concentration (0.1-20mM)- and treatment (24-72h)-dependent manner by activating caspase-3, -8, and -9. In the gene expression assay using a DNA microalley, adenosine upregulated mRNAs for tumor necrosis factor (TNF), TNF receptor 1-associated death domain protein (TRADD), TNF related apoptosis-inducing ligand receptor 2 (TRAIL-R2), TRADD/receptor-interacting protein kinase 1 (RIPK1), Fas-associated death domain protein (FADD), and caspase-9, involving activation of caspase-8 and -9 followed by the effector caspase-3. The results of the present study suggest that adenosine induces HepG2 cell apoptosis by activating those caspases as a result from tuning apoptosis-mediator gene transcription.


Subject(s)
Adenosine/pharmacology , Apoptosis/physiology , Carcinoma, Hepatocellular/genetics , Liver Neoplasms/genetics , Transcription, Genetic , Apoptosis/drug effects , Carcinoma, Hepatocellular/pathology , Caspase 9/drug effects , Caspase 9/metabolism , Caspases/drug effects , Caspases/metabolism , Cell Cycle/drug effects , Cell Line, Tumor , Cell Survival/drug effects , Enzyme Activation , Gene Expression Regulation, Neoplastic , Humans , Kinetics , Liver Neoplasms/pathology , RNA, Messenger/genetics , RNA, Neoplasm/genetics , Receptors, Tumor Necrosis Factor/drug effects , Receptors, Tumor Necrosis Factor/physiology , Transcription, Genetic/drug effects , Up-Regulation
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