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1.
J Gastroenterol ; 36(10): 710-7, 2001 Oct.
Article in English | MEDLINE | ID: mdl-11686483

ABSTRACT

A 68-year-old man was admitted to our hospital because of epigastric pain. An upper gastrointestinal contrast study and endoscopy revealed a II c type tumor in the posterior wall of the pyloric antrum. and computed tomography showed lymph node enlargement along the left gastric artery. Operation was performed after a presumptive diagnosis of gastric cancer with lymph node involvement. During the laparotomy, more extensive lymphadenopathy was found than was detected preoperatively, and tumor metastasis was suspected because of its firmness. Distal partial gastrectomy with D, and more extensive lymph node dissection were performed. Subsequently, the histology of permanent sections revealed not tumor metastasis but a sarcoid-like reaction in the lymph nodes. The patient recovered uneventfully: however, he was killed in an accident 38 months after the surgery. A postmortem examination was not performed, but there had been no clinical signs of either recurrence of gastric cancer or sarcoidosis.


Subject(s)
Lymph Nodes/pathology , Lymphatic Diseases/pathology , Sarcoidosis/pathology , Stomach Neoplasms/pathology , Aged , Diagnosis, Differential , Endoscopy , Humans , Lymph Nodes/surgery , Lymphatic Diseases/complications , Lymphatic Metastasis , Male , Neoplasm Staging , Sarcoidosis/complications , Stomach Neoplasms/complications , Tomography, X-Ray Computed
3.
Biochem Biophys Res Commun ; 119(3): 920-5, 1984 Mar 30.
Article in English | MEDLINE | ID: mdl-6712677

ABSTRACT

The fate of 3H-thymidine incorporated into newly synthesized DNA of CHO cells was analyzed by either the estimation of the incorporated radioactivity per cell or sedimentation in alkaline sucrose gradient. Under conditions in which DNA synthesis proceeded continuously, the incorporated radioactivity was periodically lost and regained during a 90 min chase, corresponding to a cyclic change in the sedimentation profiles. When DNA synthesis was inhibited by hydroxyurea no cyclic change of the incorporated radioactivity was observed. The cyclic changes were regarded as the result of an actual metabolic change in 3H-labelled DNA probably joining to one of the newly formed sister strands of DNA and the loss of radioactivity seems to require active continued DNA synthesis.


Subject(s)
DNA Replication , DNA/genetics , Animals , Cell Line , Cricetinae , Cricetulus , DNA/isolation & purification , DNA/metabolism , DNA Replication/drug effects , Female , Hydroxyurea/toxicity , Kinetics , Ovary
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