ABSTRACT
The purpose of this study was to evaluate serum prolidase activity in patients with developmental dysplasia of the hip (DDH). Prolidase enzyme activity was measured spectrophotometrically to pointing out the collagen metabolism. The prolidase activity in patients with DDH was significantly higher than that in the control group (p = 0.002). Furthermore, there was positive correlation between prolidase activity and dysplasia level. Increased serum prolidase activity may have played a role in the presence of DDH. We therefore hypothesized that the increased prolidase activity related to collagen turnover may be associated with etiopathogenesis and/or the progression of the disease.
Subject(s)
Dipeptidases/metabolism , Hip Dislocation, Congenital/enzymology , Adolescent , Child , Collagen/metabolism , Disease Progression , Female , Humans , MaleABSTRACT
The familial type of congenital split-hand associated with aplasia of the tibia is a very rare anomaly. Moreover, bilateral involvement of the hands and legs of the individual case is much rarer. In this paper, a case showing bilateral split-hand associated with bilateral tibial aplasia is presented, being the fourth case reported in the literature. The relevant literature is also reviewed.
