ABSTRACT
We examined 150 pregnant women with essential hypertension (EHT), EHT and connective tissue dysplasia (CTD), and healthy. Presence of CTD aggravated clinical picture of EHT and was associated with pronounced cardialgic, neurological, asthenic, vertebrogenic, visceral, and other syndromes. The use of antihypertensive, metabolic (magnesium orotate) drugs, sedative and uroseptic phytotherapy, application of other nondrug measures in conditions of multidisciplinary dynamic support of the gestational period facilitated regress of clinical symptoms of EHT and EHT+CTD, favorable course of pregnancy and successful delivery.
Subject(s)
Antihypertensive Agents/administration & dosage , Connective Tissue Diseases/drug therapy , Hypertension/drug therapy , Orotic Acid/analogs & derivatives , Pregnancy Complications, Cardiovascular/drug therapy , Adult , Blood Pressure/drug effects , Connective Tissue Diseases/diagnosis , Connective Tissue Diseases/metabolism , Connective Tissue Diseases/physiopathology , Dietary Supplements , Drug Monitoring , Drug Therapy, Combination , Echocardiography/methods , Female , Humans , Hypertension/diagnosis , Hypertension/metabolism , Hypertension/physiopathology , Orotic Acid/administration & dosage , Perinatal Mortality , Pregnancy , Pregnancy Complications, Cardiovascular/diagnosis , Pregnancy Complications, Cardiovascular/metabolism , Pregnancy Complications, Cardiovascular/physiopathology , Pregnancy Outcome , Severity of Illness Index , Siberia , Treatment OutcomeABSTRACT
From 2000 to 2011 in prospective and retrospective studies we investigated pregnancy outcomes in all 30417 women treated within framework of the multidisciplinary management system for pregnant patients with cardiovascular diseases (hypertension, structural heart disease, aortic pathology and inflammatory autoimmune rheumatic diseases) designed and conducted in the Udmurt Republic of Russian Federation in late 1980-th. The system comprises specialized outpatient and inpatient departments, sanatorium and a maternity hospital at the regional cardiological center and provides ambulatory and hospital management and rehabilitation. Perinatal mortality decreased 65.8% from 11.1% in 2000 to 3.8% in 2011. Within 20 years no mother died.