ABSTRACT
Experiments on albino rats showed that pyrimidine derivatives reduce hemorrhagic damage of the gastric mucosa caused by indomethacin, acetylsalicylic acid, and ortophen. The derivatives of pyrimidine prevent the decrease in total acid phosphatase activity, increase alkaline phosphatase, and reduce the activity of lactate dehydrogenase.
Subject(s)
Anti-Ulcer Agents/therapeutic use , Pentoxyl/analogs & derivatives , Pyrimidines/therapeutic use , Stomach Ulcer/drug therapy , Uracil/analogs & derivatives , Animals , Anti-Inflammatory Agents, Non-Steroidal , Aspirin , Diclofenac , Disease Models, Animal , Drug Evaluation, Preclinical , Indomethacin , Pentoxyl/therapeutic use , Rats , Stomach Ulcer/chemically induced , Uracil/therapeutic useABSTRACT
Pyrimidine derivatives increased the antibiotic therapy efficacy in albino rats irradiated with RUM-7 apparatus for close-focus roentgenotherapy. 2-Methyl-4-amino-6-oxypyrimidine was twice as efficient as oxymethyluracil and 6 times as efficient as methyluracil in the stimulation of the skin reparative regeneration. When the total irradiation was performed with LUCH-1 apparatus in a dose of 6 Gy the pyrimidine derivatives also increased the antibiotic therapy efficacy. After the prophylactic use of the pyrimidine derivatives for 7 days prior to the total irradiation their therapeutic effect increased, the level of the exudative component lowered, the tissue epithelization increased, the terms of the wound healing decreased and the animal lifespan increased.
Subject(s)
Anti-Bacterial Agents/therapeutic use , Chloramphenicol/therapeutic use , Pyrimidines/pharmacology , Radiation Injuries, Experimental/drug therapy , Radiation-Protective Agents/pharmacology , Skin/drug effects , Wound Healing/drug effects , Administration, Topical , Animals , Anti-Bacterial Agents/administration & dosage , Blood Cell Count , Burns/blood , Burns/complications , Burns/drug therapy , Chloramphenicol/administration & dosage , Drug Therapy, Combination , Pyrimidines/therapeutic use , Radiation Injuries, Experimental/blood , Radiation Injuries, Experimental/complications , Radiation-Protective Agents/therapeutic use , Rats , Skin/radiation effects , Uracil/analogs & derivatives , Uracil/pharmacology , Uracil/therapeutic use , Whole-Body Irradiation , Wound Healing/radiation effectsABSTRACT
It was shown on noninbred albino rats with various affections of the skin that pyrimidine derivatives stimulated the skin reparative regeneration and increased the efficacy of antibiotic therapy of Staphylococcus and Proteus infected wounds. The therapeutic effect of 2-methyl-4-amino-6-oxypyrimidine was much higher than that of oxymethyluracil or methyluracil. The pyrimidine derivatives proved to be universal accelerators for reparative regeneration, were compatible with antibiotics and increased their efficacy.
