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1.
Article in English | MEDLINE | ID: mdl-22356235

ABSTRACT

This work deals with the synthesis of a new nitrogen mustard derivative based on thymine. To introduce the bis(2-chloroethyl)amine group to position 4 of the pyrimidine base, many strategies were explored and the desired compound was finally obtained, thanks to a synthetic pathway in five steps.


Subject(s)
Antineoplastic Agents, Alkylating/chemical synthesis , Mechlorethamine/chemical synthesis , Thymine/chemistry , Alkylation , Antineoplastic Agents, Alkylating/chemistry , Ethanolamines/chemistry , Mechlorethamine/chemistry , Molecular Structure
2.
Steroids ; 77(1-2): 91-9, 2012 Jan.
Article in English | MEDLINE | ID: mdl-22064216

ABSTRACT

We have demonstrated previously that the brassinosteroid (BR) 24-epibrassinolide exerts neuroprotective effects deriving from its antioxidative properties. In this study, we synthesized 2 natural BRs and 5 synthetic analogs and analyzed their neuroprotective actions in neuronal PC12 cells, against 1-methyl-4-phenylpyridinium (MPP(+)), a neurotoxin known to induce oxidative stress and degenerescence of dopaminergic neurons characteristic of Parkinsonian brains. We also tested the neuroprotective potential of 2 commercially available BRs. Our results disclosed that 6 of the 9 BRs and analogs tested protected neuronal PC12 cells against MPP(+) toxicity. In addition, our structure-activity study suggests that the steroid B-ring and lateral chain play an important role for their neuroprotective action.


Subject(s)
1-Methyl-4-phenylpyridinium/adverse effects , Antioxidants/chemical synthesis , Brassinosteroids/chemical synthesis , Dopaminergic Neurons/drug effects , Neuroprotective Agents/chemical synthesis , Parkinson Disease/prevention & control , Animals , Antioxidants/pharmacology , Antioxidants/therapeutic use , Brassinosteroids/pharmacology , Brassinosteroids/therapeutic use , Dopaminergic Neurons/cytology , Dopaminergic Neurons/metabolism , Humans , Molecular Structure , Neuroprotective Agents/pharmacology , Neuroprotective Agents/therapeutic use , Oxidative Stress , PC12 Cells , Parkinson Disease/metabolism , Parkinson Disease/pathology , Rats , Structure-Activity Relationship
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