ABSTRACT
A series of phytoecodysteroids, including alpha-ecdysone, 2-deoxy-alpha-ecdysone, and 2-deoxyecdysterone isolated from Silene praemixta, integristerone A and ecdysterone isolated from Rhaponticum carthamoides and 22-acetylcyasterone and turkesterone isolated from Ajuga turkestanica, exhibit a pronounced hypoglycemic effect in experiments on intact male rats. The most active compounds--ecdysteron and turkesterone--also produce an expressed hypoglycemic effect in animals with model hyperglycemia induced by the administration of glucose, adrenalin and alloxan. Phytoecdysteroids are substances possessing protein-anabolic activity and are somewhat similar to steranobols in this aspect. Phytoecdysteroids exhibit unidirectional effect and are well comparable with steranabol actionon the carbohydrate metabolism.
Subject(s)
Blood Glucose/drug effects , Ecdysteroids/pharmacology , Hyperglycemia/drug therapy , Hypoglycemic Agents/pharmacology , Ajuga/chemistry , Animals , Asteraceae/chemistry , Blood Glucose/metabolism , Caryophyllaceae/chemistry , Ecdysteroids/chemistry , Ecdysterone/analogs & derivatives , Ecdysterone/chemistry , Ecdysterone/pharmacology , Hypoglycemic Agents/chemistry , Male , Methandrostenolone/chemistry , Methandrostenolone/pharmacology , Phytosterols/chemistry , Phytosterols/pharmacology , RatsABSTRACT
In the paper are presented the data on revealement of cryptosporidian oocysts (Apicomplexa, Sporozoa) in feces of cattle, swine and sheep of different ages and results of the experimental infection of laboratory animals (rats, mice, rabbits, coypus) with the oocysts detected as well. The latters were attributed to Cryptosporidium parvum species. The analysis of the size characteristic in the isolates of naturally and artificially infected hosts has shown that the oocysts dimensions might vary both in different host species and in different individuals of one host species.
