The Affordable Care Act and orthopaedic trauma.

The Affordable Care Act has resulted in a dramatic governmental restructuring of the healthcare insurance market and delivery system. Orthopaedic traumatologists must be aware of the law's impact on their clinical practice, finances, and overall business model. This includes the effect of accountable care organizations, the Independent Payment Advisory Board, and the Physician Value-Based Payment Modifier program, as well as the impact of the Affordable Care Act's grace period provision, medical device excise tax, and cuts to funding for the Disproportionate Share Hospital program.

Health literacy in an orthopaedic trauma patient population: improving patient comprehension with informational intervention.

OBJECTIVES: This study aims to evaluate the change in comprehension of diagnoses, treatment plans, and discharge instructions after orthopaedic trauma patients are given an informational document that includes pictorial representations at the time of discharge. It also seeks to determine if the intervention has a greater impact on patients with lower educational backgrounds. DESIGN: Prospective comparative cohort study. SETTING: Academic level 1 trauma center. PATIENTS: From April to December 2011, 529 orthopaedic trauma patients with an operatively fixed isolated fracture were eligible for inclusion. Two hundred ninety-nine eligible questionnaires were collected (56.5% response rate). INTERVENTION: Patients were administered a questionnaire regarding their treatment and discharge instructions during their first postoperative clinic visit before being seen by a physician. The questionnaire included demographic information and questions regarding: (1) which bone was fractured, (2) type of implanted fixation, (3) weight-bearing status, (4) expected recovery time, and (5) need for deep vein thrombosis prophylaxis. All patients had received verbal instructions outlining this information at postoperative hospital discharge. During the second half of the study, patients were given an additional informational sheet with both text and pictorial representations at discharge. Multivariable log-binomial regression analyses were used to examine the impact of this intervention. RESULTS: One hundred forty-six patients were given only the standard discharge instructions, whereas 153 patients were also administered the additional information document. The mean score for patients who received the intervention was 2.90 (out of 5) compared with the mean score of 2.54 for patients who did not receive the intervention (P = 0.013). Patients who received the intervention were 1.3 times more likely to know which bone was fractured (P = 0.007) and 1.1 times more likely to be able to correctly name the medication(s) they were prescribed for deep vein thrombosis prophylaxis (P = 0.03). CONCLUSIONS: Overall performance on comprehension questionnaires in orthopaedic trauma patients was significantly improved via a text and pictorial intervention. The intervention did not preferentially aid patients with lower education backgrounds. Future studies should evaluate long-term postoperative results to determine if improved patient comprehension has an effect on surgical outcomes and patient satisfaction.

Treating post-traumatic tremor with deep brain stimulation: report of five cases.

BACKGROUND: Post-traumatic tremor is one of the most common movement disorders resulting from severe head trauma. However, literature regarding successful deep brain stimulation (DBS) treatment is scarce, resulting in ambiguity regarding the optimal lead location. Most cases support the ventral intermediate nucleus, but there is evidence to defend DBS of the zona incerta, ventral oralis anterior/posterior, and/or a combination of these targets. We report five patients with disabling post-traumatic tremor treated with DBS of the ventral intermediate nucleus and of the globus pallidus internus. METHODS: Patients were referred to the Vanderbilt Movement Disorders Division, and surgical intervention was determined by a DBS Multidisciplinary Committee. Standard DBS procedure was followed. RESULTS: Patients 1-4 sustained severe diffuse axonal injuries. Patients 1-3 underwent unilateral ventral intermediate nucleus DBS for contralateral tremor, while Patient 4 underwent bilateral ventral intermediate nucleus DBS. Patients 1-3 experienced good tremor reduction, while Patient 4 experienced moderate tremor reduction with some dystonic posturing of the hands. Patient 5 had dystonic posturing of the right upper extremity with tremor of the left upper extremity. He was treated with bilateral DBS of the globus pallidus internus and showed good tremor reduction at follow-up. CONCLUSION: Unilateral or bilateral DBS of the ventral intermediate nucleus and bilateral DBS of the globus pallidus internus may be effective and safe treatment modalities for intractable post-traumatic tremor. Further studies are needed to clarify the optimal target for surgical treatment of post-traumatic tremor.

Appendiceal duplication in children presenting as an appendiceal tumor and as recurrent intussusception.

Duplication of the appendix is a rare condition and is usually an incidental finding during an appendectomy. There have been several cases reported in the literature. Although not usually associated with any discrete pathology, the presenting symptoms can vary but are usually associated with acute appendicitis. We present two cases of appendiceal duplication in young children, one presenting with the usual signs and symptoms of acute appendicitis and the other with intussusception. The purpose of this report is to present two distinct modes of presentation of this rare condition so that pediatric general surgeons are aware of this as a possible entity.

The role of the CXCR4 cell surface chemokine receptor in glioma biology.

CXCR4, a cell surface chemokine receptor, mediates cellular dissemination, invasion, and proliferation in a wide range of cancers including gliomas. It is over-expressed in glioma progenitor cells, and its protein ligand, CXCL12, has been shown to mediate a specific proliferative response in these cells thereby implicating a role for CXCR4 in glioma initiation and renewal. Given the failure of currently employed therapies to meaningfully impact prognosis in patients with high-grade gliomas, the CXCR4-CXCL12 axis represents a novel biologically relevant mechanism that could be specifically targeted for therapy. From this perspective, this review summarizes the biological effects of CXCR4 activity and its implications for glioma pathogenesis. Ultimately, the development of effective treatment approaches for malignant glioma must be based on a rational mechanistic understanding of tumor cell biology. As such, this article presents such a framework with regard to the CXCR4 pathway in glioma thereby supporting the further investigation of CXCR4 as a therapeutic target in patients with this disease.

The link between texting and motor vehicle collision frequency in the orthopaedic trauma population.

BACKGROUND: This study will evaluate whether or not texting frequency while driving and/or texting frequency in general are associated with an increased risk of incurring a motor vehicle collision (MVC) resulting in orthopaedic trauma injuries. METHODS: All patients who presented to the Vanderbilt University Medical Center Orthopaedic Trauma Clinic were administered a questionnaire to determine background information, mean phone use, texting frequency, texting frequency while driving, and whether or not the injury was the result of an MVC in which the patient was driving. RESULTS: 237 questionnaires were collected. 60 were excluded due to incomplete date, leaving 57 questionnaires in the MVC group and 120 from patients with non-MVC injuries. Patients who sent more than 30 texts per week ("heavy texters") were 2.22 times more likely to be involved in an MVC than those who texted less frequently. 84% of respondents claimed to never text while driving. Dividing the sample into subsets on the basis of age (25 years of age or below considered "young adult," and above 25 years of age considered "adult"),young, heavy texters were 6.76 times more likely to be involved in an MVC than adult non-heavy texters (p = 0.000). Similarly, young adult, non-heavy texters were 6.65 (p = 0.005) times more likely to be involved in an MVC, and adult, heavy texters were 1.72 (p = 0.186) times more likely to be involved in an MVC. CONCLUSIONS: Patients injured in an MVC sent more text messages per week than non-MVC patients. Additionally, controlling for age demonstrated that young age and heavy general texting frequency combined had the highest increase in MVC risk, with the former being the variable of greatest effect.

Health literacy in an orthopedic trauma patient population: a cross-sectional survey of patient comprehension.

OBJECTIVES: The aim of this study was to evaluate the level of comprehension in an orthopedic trauma patient population regarding injury, surgery, and postoperative instructions and to determine if educational background is associated with inadequate comprehension. DESIGN: This involved a prospective observational cohort. SETTING: The study was conducted at an Academic Level 1 trauma center. PATIENTS: From April to June 2011, 248 orthopedic trauma patients with an operatively fixed isolated fracture were found to be eligible for inclusion. One hundred forty-six eligible questionnaires were collected (58.9% response rate). INTERVENTION: The patients were administered a questionnaire during their first postoperative visit before being seen by a physician. The questionnaire included demographic information and questions regarding (1) which bone was fractured; (2) the type of implanted fixation; (3) weight-bearing status; (4) expected recovery time; and (5) need for deep vein thrombosis (DVT) prophylaxis. Multivariable logistic regression analyses were used to examine the association between educational level and questions regarding surgical procedure and discharge instructions. RESULTS: The overall mean score of all the patients on the patient comprehension portion was 2.54 ± 1.27 correct responses out of 5. Only 47.9% of patients knew the bone they fractured, and 18.5% knew their expected healing time. Of the patients, 66.4% knew the type of implanted fixation, and 45.2% knew their weight-bearing status. The patients (74.0%) knew their DVT prophylaxis medication(s). The mean score for patients in the group ≤ HS (high-school education or less) was 2.26, whereas the mean score for patients in the group > HS (more than high-school education) was 3.00 (P = 0.0009). The patients in the group > HS were 2.54 times more likely to know the bone they fractured (P = 0.01), 3.82 times more likely to know the recovery time (P = 0.004), and 2.79 times more likely to know their DVT prophylaxis medication(s) than patients in the group ≤ HS. CONCLUSIONS: Orthopedic trauma patients demonstrated limited comprehension of their injuries, surgeries, and postoperative instructions. Patients with lower educational levels did significantly worse on the questionnaire than those with higher educational levels. The results of the study highlight a lack of comprehension within this patient population and suggest that an increased focus on patient communication by orthopedic providers may be necessary.