[Water-electrolyte and hemodynamic aspects of the lasix test in patients with various courses of hypertension]. / Vodno-élektrolitnye i gemodinamicheskie aspekty proby s laziksom u bol'nykh s razlichnym techeniem gipertonicheskoi bolezni.

Forty-two hypertensive patients and seven controls were subjected to the lasix test (20 mg intravenously) followed by the assessment of the time-course of water and electrolytes excretion as well as by arterial pressure measurements. Prior to the test the authors, using isotopic and non-isotopic dilutions, determined the indices of central hemodynamics and sodium, potassium and water distribution in the body. In more than 60% of the patients, the diuretic, sodium- and potassiumuretic response to the administration of lasix was higher than in control. In the patients with essential hypertension, the nature of this response did not depend on the initial level of the arterial pressure, cardiac index, rate of glomerular filtration, content of the total metabolic sodium and potassium, or on the amount and distribution of water in the extracellular and intracellular spaces of the body. The patients with an excessive response to lasix had a significantly lower baseline urine excretion of stable sodium, a higher sodium concentration in the red blood cells and, in cases of stable hypertension, a higher activity of plasma renin as well. Modifications in hypotensive therapy are proposed in relation to the response to lasix administration.

[Changes in water-sodium balance in patients with hypertension subjected to different types of hypotensive therapy]. / Kharakter vodno-natrievykh izmenenii v organizme bol'nykh gipertonicheskoi bolezn'iu pod vliianiem razlichnykh vidov gipotenzivnoi terapii.

The parameters of water-electrolyte metabolism and central hemodynamics were studied in 44 patients with essential hypertension (stage II-III) after 3-week treatment with sympatholytics and diuretics. Patients with hyperkinetic type of hemocirculation had a sodium lack at the stage of stable hypertension, therefore the diuretic treatment is not indicated for such patients. The treatment with the diuretic oxodolin was accompanied by the decrease in the peripheral resistance of blood vessels, in sodium metabolism and its extracellular fraction, and by the increase of the deposit sodium fraction. The elevation of the renin-angiotensin system activity due to the diuretic therapy did not influence the blood pressure level and the central hemodynamics parameters.