ABSTRACT
Recently, nanocarriers that transport bioactive substances to a target site in the body have attracted considerable attention and undergone rapid progression in terms of the state of the art. However, few nanocarriers can enter the brain via a systemic route through the blood-brain barrier (BBB) to efficiently reach neurons. Here we prepare a self-assembled supramolecular nanocarrier with a surface featuring properly configured glucose. The BBB crossing and brain accumulation of this nanocarrier are boosted by the rapid glycaemic increase after fasting and by the putative phenomenon of the highly expressed glucose transporter-1 (GLUT1) in brain capillary endothelial cells migrating from the luminal to the abluminal plasma membrane. The precisely controlled glucose density on the surface of the nanocarrier enables the regulation of its distribution within the brain, and thus is successfully optimized to increase the number of nanocarriers accumulating in neurons.There are only a few examples of nanocarriers that can transport bioactive substances across the blood-brain barrier. Here the authors show that by rapid glycaemic increase the accumulation of a glucosylated nanocarrier in the brain can be controlled.
Subject(s)
Blood Glucose/metabolism , Blood-Brain Barrier/metabolism , Brain/metabolism , Drug Carriers/pharmacokinetics , Animals , Brain/blood supply , Drug Carriers/metabolism , Female , Glucose/metabolism , Glucose Transporter Type 1/metabolism , Glycosylation , Humans , Mice, Inbred BALB C , Micelles , Microscopy, Confocal , Nanoparticles/metabolism , Neurons/metabolism , Polymers/chemistry , Polymers/metabolismABSTRACT
To investigate whether it is possible to control the wetting of ^{4}He crystals on a wall in superfluid, the contact angles of ^{4}He crystals were measured on rough and smooth walls at very low temperatures. A rough wall was prepared in a simple manner in which a commercially available coating agent for car mirrors, which makes the glass surface superhydrophobic, was used to coat a glass plate. The contact angles of ^{4}He crystals were increased by approximately 10^{∘} on the rough wall coated with the agent. Therefore, the increase in the repellency of ^{4}He crystals in superfluid was demonstrated to be possible on a very rough surface. The enhancement of the contact angles and a scanning electron microscopy image of the coated surface both suggest that a Cassie-Baxter state of ^{4}He crystals was realized on the surface; the crystals did not have full contact with the wall, but entrapped superfluid was present beneath the crystals in the hollow parts of the rough wall.
ABSTRACT
Magneto-optical imaging in YBa(2)Cu(3)O(7-delta) with tilted columnar defects (CD's) shows an asymmetric critical-state field profile. The observed hysteretic shift of the profile ridge (trough) from the center of the sample is explained by in-plane magnetization originating from vortex alignment along CD's. The extracted ratio of the in-plane to out-of-plane magnetization component has a maximum at 1/5 of matching field ( B(Phi)) and disappears above B(Phi)/3, suggesting a reduction of interlayer coherence well below B(Phi) in the Bose glass phase. Implications are discussed in comparison with the vortex liquid recoupling observed in irradiated Bi(2)Sr(2)CaCu(2)O(8+y).
