Analysis of labour accidents caused by slope failure during slope cutting and application of a rapid checklist for risk management in Japan.

Slope failure during or immediately after slope-cutting can cause fatal accidents. This study analyses the characteristics of labour accidents caused by slope failure during slope-cutting in Japan and presents a countermeasure to prevent accidents caused by slope failure, such as the implementation of a slope guideline by MHLW. A case history conducted during slope-cutting and nailing was presented as an example of the application of the slope guideline to ensure safety. Furthermore, monitoring methods were implemented to gain a quantitative understanding of slope deformation. Geological conditions other than those assumed prior to excavation and small collapses attributed to groundwater are indications of landslide risk. The guideline's quick checklist reflects the slope condition or deformation, allowing the client, designer and contractor to discuss and agree on a quick solution to a problem. The case study confirmed the effectiveness of the slope guideline as a tool for sharing information during construction.

Unstable behavior of segmental ring under various pressures and its discrete element simulation.

In February 2012, a serious accident which resulted in five fatalities happened during a TBM-tunnel construction under the seabed in Japan. The cause of the accident appeared to be due to the Key-segment slipping out of the segment ring by the thrusting tailskin (wire brushes) of the TBM into the segment ring. This resulted in the collapse of the rings, causing the seabed ground and seawater to flow into the tunnel. We investigated how thin and thick segments without any circumferential joints behave under isotropic and anisotropic pressures using small-scale physical model. In the model tests, pressures were applied to the surroundings of the segment rings and the strains at each segment were measured in order to evaluate the damage. In addition, cases where lubrication on the contact area between the K- and B-segments was present or not were investigated and their discrete element simulations were also conducted.

Analysis of labour accidents in tunnel construction and introduction of prevention measures.

At present, almost all mountain tunnels in Japan are excavated and constructed utilizing the New Austrian Tunneling Method (NATM), which was advocated by Prof. Rabcewicz of Austria in 1964. In Japan, this method has been applied to tunnel construction since around 1978, after which there has been a subsequent decrease in the number of casualties during tunnel construction. However, there is still a relatively high incidence of labour accidents during tunnel construction when compared to incidence rates in the construction industry in general. During tunnel construction, rock fall events at the cutting face are a particularly characteristic of the type of accident that occurs. In this study, we analysed labour accidents that possess the characteristics of a rock fall event at a work site. We also introduced accident prevention measures against rock fall events.

The major DNA repair pathway after both proton and carbon-ion radiation is NHEJ, but the HR pathway is more relevant in carbon ions.

The purpose of this study was to identify the roles of non-homologous end-joining (NHEJ) or homologous recombination (HR) pathways in repairing DNA double-strand breaks (DSBs) induced by exposure to high-energy protons and carbon ions (C ions) versus gamma rays in Chinese hamster cells. Two Chinese hamster cell lines, ovary AA8 and lung fibroblast V79, as well as various mutant sublines lacking DNA-PKcs (V3), X-ray repair cross-complementing protein-4 [XRCC4 (XR1), XRCC3 (irs1SF) and XRCC2 (irs1)] were exposed to gamma rays ((137)Cs), protons (200 MeV; 2.2 keV/µm) and C ions (290 MeV; 50 keV/µm). V3 and XR1 cells lack the NHEJ pathway, whereas irs1 and irs1SF cells lack the HR pathway. After each exposure, survival was measured using a clonogenic survival assay, in situ DSB induction was evaluated by immunocytochemical analysis of histone H2AX phosphorylation at serine 139 (γ-H2AX foci) and chromosome aberrations were examined using solid staining. The findings from this study showed that clonogenic survival clearly depended on the NHEJ and HR pathway statuses, and that the DNA-PKcs(-/-) cells (V3) were the most sensitive to all radiation types. While protons and γ rays yielded almost the same biological effects, C-ion exposure greatly enhanced the sensitivity of wild-type and HR-deficient cells. However, no significant enhancement of sensitivity in cell killing was seen after C-ion irradiation of NHEJ deficient cells. Decreases in the number of γ-H2AX foci after irradiation occurred more slowly in the NHEJ deficient cells. In particular, V3 cells had the highest number of residual γ-H2AX foci at 24 h after C-ion irradiation. Chromosomal aberrations were significantly higher in both the NHEJ- and HR-deficient cell lines than in wild-type cell lines in response to all radiation types. Protons and gamma rays induced the same aberration levels in each cell line, whereas C ions introduced higher but not significantly different aberration levels. Our results suggest that the NHEJ pathway plays an important role in repairing DSBs induced by both clinical proton and C-ion beams. Furthermore, in C ions the HR pathway appears to be involved in the repair of DSBs to a greater extent compared to gamma rays and protons.