Subject(s)
Adjuvants, Immunologic/therapeutic use , Antioxidants/therapeutic use , Ceruloplasmin/therapeutic use , Orthomyxoviridae Infections/drug therapy , Animals , Cyclic AMP/metabolism , Cyclic GMP/metabolism , Hemagglutinins, Viral/immunology , Killer Cells, Natural/immunology , Male , Mice , Mice, Inbred Strains , Orthomyxoviridae Infections/blood , Orthomyxoviridae Infections/metabolismABSTRACT
The permanent action of small doses of low-intensity radiation on the immune status of 2.5-3.5 month CC57W mice has been investigated. Total doses of internal and external irradiation were about few cGy. The permanent action of low-level radiation on the experimental animals of the first and fourth generations was shown to change spleen and lymph nodes weights and the count of lymphocytes isolated from these organs. Cellularity and DNA synthesis in the lymph-node lymphocytes and their proliferative response to polyclonal mitogens also changed. The alterations in the parameters that characterized T-lymphocyte population were statistically significant.
Subject(s)
Accidents , Immune System/radiation effects , Immunocompetence/radiation effects , Nuclear Reactors , Power Plants , Animals , Body Weight/radiation effects , Dose-Response Relationship, Radiation , Environmental Exposure , Immune System/pathology , Male , Mice , Mice, Inbred C57BL , Organ Size/radiation effects , Time Factors , UkraineABSTRACT
The immune status of mice has been assessed by the whole complex of data. The permanent action of low-level radiation has been shown to suppress considerably the rate of reactions of the delayed-type hypersensitivity and "graft versus host" disease, as well as NK and specific cytolytic T-lymphocyte activity. The dynamics of accumulation and the levels of antiviral antibodies in the serum, lung and trachea extracts are virtually invariable. The resistance of experimental animals to influenza is lower than that of non-irradiated mice of the same line and age. The data obtained indicate that the immune disturbances revealed are connected not only with the alteration of lymphoid cell populations, but also with the alteration of the immune regulation mechanisms.
Subject(s)
Accidents , Aging/radiation effects , Lymphocyte Cooperation/radiation effects , Nuclear Reactors , Power Plants , Aging/immunology , Animals , Environmental Exposure , Female , Graft vs Host Reaction/immunology , Graft vs Host Reaction/radiation effects , Hypersensitivity, Delayed/immunology , Immunity, Innate/immunology , Immunity, Innate/radiation effects , Influenza A virus , Lymphocyte Cooperation/immunology , Male , Mice , Mice, Inbred C57BL , Orthomyxoviridae Infections/immunology , UkraineABSTRACT
In mice infected with influenza A2/Port Chalmers and B/Hong Kong viruses the formation of antibody-producing cells (APC) to the thymus-dependent antigen, sheep red blood cells (SRBC) was found to be inhibited much stronger than that to the thymus-independent antigen (polyvinylpyrrolidone K-90). Influenza A/PR-8/34 virus was approximately similarly active in both systems. Spleen cells of mouse donors infected with influenza virus were characterized by a markedly reduced capacity to form APC to ARBC when inoculated into irradiated recipients. This capacity was recovered if the donor spleen cells of infected animals were inoculated into recipients in mixture with T-lymphocytes of intact animals. Possible mechanisms of lymphocyte damage in influenza infection are discussed.
