[Characteristic of oxidative metabolism and microsomal enzyme system of the liver in patients with chronic circulation insufficiency]. / Kharakteristika okislitel'nogo metabolizma i mikrosomal'noí fermentnoí sistemy pecheni u bol'nykh s khronicheskoí nedostatochnost'iu krovoobrashcheniia.

The examination of 52 patients with circulation insufficiency class II-III (CI) provided evidence on suppressed monooxygenase system of the liver brought by lipid peroxidation (LPO) activation in CI of different etiology. The severity of the above changes was related to CI class. LPO intensification weakens anti-oxidant defense and promotes enhancement of endogenic intoxication. The latter becomes most pronounced in CI of the III degree.

[Hepatic blood flow and the liver mono-oxygenase system in patients with ischemic heart disease]. / Sostoianie pechenochnogo krovotoka i monooksigenaznoi sistemy pecheni u bol'nykh ishemicheskoi bolezn'iu serdtsa.

The hepatic blood flow and monooxygenase system activity were studied in 68 ischemic [correction of coronary] heart disease patients aged 37-68 [correction of 40-80] years who had functional class III-IV effort angina and 12 healthy volunteers matched by age. An analysis of the finding indicated that in patients with angina pectoris, the hepatic blood flow index decreased, the pharmacokinetic parameters of antipyrin impaired, the degree of these impairments depended on the severity of the clinical course of angina pectoris.